[3dem] Post-doctoral position in cryo-EM of membrane receptor kinases

[Pierre Maisonneuve]

Dear colleagues, 

 
We have an open position for a highly motivated postdoctoral candidate in the group of Pierre Maisonneuve in Bordeaux at the CBMN (UMR5248, CNRS, France) to investigate the structural basis of membrane receptor kinases signaling by cryo-EM. Our lab benefits from an exciting and multidisciplinary scientific environment with on-site access to cutting-edge facilities in Cryo-EM, X-Ray crystallography, NMR, Biochemistry, Biophysics, molecular biology and cell biology. 



Applicants must have a Ph.D. in structural biology, biochemistry, biophysics or related fields. We are seeking an exceptional post-doctoral candidate with expertise in protein biochemistry (ideally in membrane protein) and with knowledge in single-particle electron microscopy (cryo-EM). Previous experience in protein expression in human cells is preferred but not required.



The project will be conducted in close collaboration with the team of Xavier Guillory (Inserm U1212, Rennes, France).

The position is fully funded by the French research agency. 



More details can be found here: https://urldefense.com/v3/__https://www.nature.com/naturecareers/job/12814745/__;!!Mih3wA!Hh5TU0SqRmXgRWh9U-Iy6A0vocGhsvJ40YSMViTEo1-rWvPlYgYjUXKBG1zz4bZZc1MsgYROcg4_uhpDHTZnEF0AmXmZJZWg3WEQ$ 



The deadline for the application is March 31st. The proposed starting date for this position is June.



Example of work that we are developing in the lab:

Maisonneuve, P.*, Sahmi, M.*, et al. The CNK–HYP scaffolding complex promotes RAF activation by enhancing KSR–MEK interaction. Nat Struct Mol Biol (2024). https://urldefense.com/v3/__https://doi.org/10.1038/s41594-024-01233-6__;!!Mih3wA!Hh5TU0SqRmXgRWh9U-Iy6A0vocGhsvJ40YSMViTEo1-rWvPlYgYjUXKBG1zz4bZZc1MsgYROcg4_uhpDHTZnEF0AmXmZJduyOn0d$ 

Posternak G*, Tang X*, Maisonneuve P*, Jin T*, Lavoie H* et al., Functional characterization of a PROTAC directed against BRAF mutant V600E. Nature Chemical Biology. 2020 Nov;16(11):1170-1178. 

Lavoie H*, Sahmi M*, Maisonneuve P* et al., MEK drives BRAF activation through allosteric control of KSR proteins. Nature. 2018 Feb 22;554(7693):549-553. *Equal Contribution

 



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