[3dem] Exciting Postdoc position in cryo-EM/muscle structural biology at UMass Chan Medical School Padron-Craig Lab

[Raul Padron]

The Padron-Craig Lab<https://urldefense.com/v3/__https://www.umassmed.edu/padron-craig/__;!!Mih3wA!C-j5PYzhpUC9W2IpGHtUTYQqlu225K-3hi5A1Ot0Cx0V276hJG6OHSswdPKjYtVrj_oHI-avw7qA0JXBpag31PLk$ > seeks a highly motivated, dynamic, and driven postdoctoral Associate to join our cryo-EM muscle structural biology team at the Division of Cell Biology and Imaging, UMass Chan Medical School<https://urldefense.com/v3/__https://www.umassmed.edu/__;!!Mih3wA!C-j5PYzhpUC9W2IpGHtUTYQqlu225K-3hi5A1Ot0Cx0V276hJG6OHSswdPKjYtVrj_oHI-avw7qA0JXBpV25tCnT$ > in Worcester, MA. The successful candidate will receive a competitive salary and benefits package.

The Padron-Craig Lab<https://urldefense.com/v3/__https://www.umassmed.edu/padron-craig/__;!!Mih3wA!C-j5PYzhpUC9W2IpGHtUTYQqlu225K-3hi5A1Ot0Cx0V276hJG6OHSswdPKjYtVrj_oHI-avw7qA0JXBpag31PLk$ > has focused on the structure of myosin molecules and muscle thick filaments since discovering the myosin interacting-heads motif (IHM) in thick filaments by cryo-EM in 2005 (Woodhead et al. Nature 436, 1195-1199, 2005<https://urldefense.com/v3/__https://www.nature.com/articles/nature03920__;!!Mih3wA!C-j5PYzhpUC9W2IpGHtUTYQqlu225K-3hi5A1Ot0Cx0V276hJG6OHSswdPKjYtVrj_oHI-avw7qA0JXBpdUicEVg$ >), leading to the 4.3 Å resolution structure of the myosin molecule in the inhibited state (Yang et al. Nature 588, 521-525, 2020<https://urldefense.com/v3/__https://www.nature.com/articles/s41586-020-3007-0__;!!Mih3wA!C-j5PYzhpUC9W2IpGHtUTYQqlu225K-3hi5A1Ot0Cx0V276hJG6OHSswdPKjYtVrj_oHI-avw7qA0JXBpS_Onx1O$ >) and the recently published 6 Å resolution structure of the human cardiac thick filament (Dutta et al Nature 623, 853-862, 2023<https://urldefense.com/v3/__https://www.nature.com/articles/s41586-023-06691-4__;!!Mih3wA!C-j5PYzhpUC9W2IpGHtUTYQqlu225K-3hi5A1Ot0Cx0V276hJG6OHSswdPKjYtVrj_oHI-avw7qA0JXBpW8xExBo$ >)

The ideal candidate to join our continuing adventure of solving the near-atomic cryo-EM structure of human muscle thick filaments and the structural impact of disease mutations will possess a broad curiosity, a passion for discovery, and an interest in the implications for muscle relaxation, activation, disease, and drug treatment.

Expertise in Structural Biology, cryo-EM/ET, X-ray Crystallography, and Molecular Dynamic simulations will be a plus but is not required, as this position (NIH-funded for 3-4 years) is an excellent opportunity to learn cryo-EM or expand your existing capabilities.

Our UMass Chan Cryo-EM Core Facility<https://urldefense.com/v3/__https://www.umassmed.edu/research/cores/cryo-em-core-facility/__;!!Mih3wA!C-j5PYzhpUC9W2IpGHtUTYQqlu225K-3hi5A1Ot0Cx0V276hJG6OHSswdPKjYtVrj_oHI-avw7qA0JXBpY8CaI6Q$ > is superbly equipped and staffed to carry out this work (Titan Krios, Talos-Arctica, Glacios, with K3 cameras and energy filters, Aquilos FIB-SEM, etc.), and provides excellent hands-on training.

Please send your cover letter and resume to raul.padron at umassmed.edu<mailto:raul.padron at umassmed.edu> and  roger.craig at umassmed.edu<mailto:roger.craig at umassmed.edu>

All the best,

Raul Padron & Roger Craig

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