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<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal" style="text-align:justify;text-justify:inter-ideograph"><a name="_Hlk163812280"><span style="font-size:12.0pt;font-family:"Arial",sans-serif;color:#6A6A6A">The
</span></a><a href="https://urldefense.com/v3/__https://www.umassmed.edu/padron-craig/__;!!Mih3wA!C-j5PYzhpUC9W2IpGHtUTYQqlu225K-3hi5A1Ot0Cx0V276hJG6OHSswdPKjYtVrj_oHI-avw7qA0JXBpag31PLk$"><span style="mso-bookmark:_Hlk163812280"><span style="font-size:12.0pt;font-family:"Arial",sans-serif">Padron-Craig Lab</span></span><span style="mso-bookmark:_Hlk163812280"></span></a><span style="mso-bookmark:_Hlk163812280"><span style="font-size:12.0pt;font-family:"Arial",sans-serif;color:#6A6A6A">
seeks a highly motivated, dynamic, and driven postdoctoral Associate to join our cryo-EM muscle structural biology team at the Division of Cell Biology and Imaging,
</span></span><a href="https://urldefense.com/v3/__https://www.umassmed.edu/__;!!Mih3wA!C-j5PYzhpUC9W2IpGHtUTYQqlu225K-3hi5A1Ot0Cx0V276hJG6OHSswdPKjYtVrj_oHI-avw7qA0JXBpV25tCnT$"><span style="mso-bookmark:_Hlk163812280"><span style="font-size:12.0pt;font-family:"Arial",sans-serif">UMass Chan Medical School</span></span><span style="mso-bookmark:_Hlk163812280"></span></a><span style="mso-bookmark:_Hlk163812280"><span style="font-size:12.0pt;font-family:"Arial",sans-serif;color:#6A6A6A">
in Worcester, MA. The successful candidate will receive a competitive salary and benefits package.<o:p></o:p></span></span></p>
<p class="MsoNormal" style="text-align:justify;text-justify:inter-ideograph"><span style="mso-bookmark:_Hlk163812280"><span style="font-size:12.0pt;font-family:"Arial",sans-serif;color:#6A6A6A"><o:p> </o:p></span></span></p>
<p class="MsoNormal" style="text-align:justify;text-justify:inter-ideograph"><span style="mso-bookmark:_Hlk163812280"><span style="font-size:12.0pt;font-family:"Arial",sans-serif;color:#6A6A6A">The
</span></span><a href="https://urldefense.com/v3/__https://www.umassmed.edu/padron-craig/__;!!Mih3wA!C-j5PYzhpUC9W2IpGHtUTYQqlu225K-3hi5A1Ot0Cx0V276hJG6OHSswdPKjYtVrj_oHI-avw7qA0JXBpag31PLk$"><span style="mso-bookmark:_Hlk163812280"><span style="font-size:12.0pt;font-family:"Arial",sans-serif">Padron-Craig Lab</span></span><span style="mso-bookmark:_Hlk163812280"></span></a><span style="mso-bookmark:_Hlk163812280"><span style="font-size:12.0pt;font-family:"Arial",sans-serif;color:#6A6A6A">
has focused on the structure of myosin molecules and muscle thick filaments since discovering the myosin interacting-heads motif (IHM) in thick filaments by cryo-EM in 2005 (</span></span><a href="https://urldefense.com/v3/__https://www.nature.com/articles/nature03920__;!!Mih3wA!C-j5PYzhpUC9W2IpGHtUTYQqlu225K-3hi5A1Ot0Cx0V276hJG6OHSswdPKjYtVrj_oHI-avw7qA0JXBpdUicEVg$"><span style="mso-bookmark:_Hlk163812280"><span style="font-size:12.0pt;font-family:"Arial",sans-serif">Woodhead
et al. Nature 436, 1195-1199, 2005</span></span><span style="mso-bookmark:_Hlk163812280"></span></a><span style="mso-bookmark:_Hlk163812280"><span style="font-size:12.0pt;font-family:"Arial",sans-serif;color:#6A6A6A">), leading to the 4.3 Å resolution structure
of the myosin molecule in the inhibited state (</span></span><a href="https://urldefense.com/v3/__https://www.nature.com/articles/s41586-020-3007-0__;!!Mih3wA!C-j5PYzhpUC9W2IpGHtUTYQqlu225K-3hi5A1Ot0Cx0V276hJG6OHSswdPKjYtVrj_oHI-avw7qA0JXBpS_Onx1O$"><span style="mso-bookmark:_Hlk163812280"><span style="font-size:12.0pt;font-family:"Arial",sans-serif">Yang et al. Nature 588, 521-525,
2020</span></span><span style="mso-bookmark:_Hlk163812280"></span></a><span style="mso-bookmark:_Hlk163812280"><span style="font-size:12.0pt;font-family:"Arial",sans-serif;color:#6A6A6A">) and the recently published 6 Å resolution structure of the human cardiac
thick filament (</span></span><a href="https://urldefense.com/v3/__https://www.nature.com/articles/s41586-023-06691-4__;!!Mih3wA!C-j5PYzhpUC9W2IpGHtUTYQqlu225K-3hi5A1Ot0Cx0V276hJG6OHSswdPKjYtVrj_oHI-avw7qA0JXBpW8xExBo$"><span style="mso-bookmark:_Hlk163812280"><span style="font-size:12.0pt;font-family:"Arial",sans-serif">Dutta et al Nature 623, 853-862, 2023</span></span><span style="mso-bookmark:_Hlk163812280"></span></a><span style="mso-bookmark:_Hlk163812280"><span style="font-size:12.0pt;font-family:"Arial",sans-serif;color:#6A6A6A">)<o:p></o:p></span></span></p>
<p class="MsoNormal" style="text-align:justify;text-justify:inter-ideograph"><span style="mso-bookmark:_Hlk163812280"><span style="font-size:12.0pt;font-family:"Arial",sans-serif;color:#6A6A6A"><o:p> </o:p></span></span></p>
<p class="MsoNormal" style="text-align:justify;text-justify:inter-ideograph"><span style="mso-bookmark:_Hlk163812280"><span style="font-size:12.0pt;font-family:"Arial",sans-serif;color:#6A6A6A">The ideal candidate to join our continuing adventure of solving
the near-atomic cryo-EM structure of human muscle thick filaments and the structural impact of disease mutations will possess a broad curiosity, a passion for discovery, and an interest in the implications for muscle relaxation, activation, disease, and drug
treatment.<o:p></o:p></span></span></p>
<p class="MsoNormal" style="text-align:justify;text-justify:inter-ideograph"><span style="mso-bookmark:_Hlk163812280"><span style="font-size:12.0pt;font-family:"Arial",sans-serif;color:#6A6A6A"><o:p> </o:p></span></span></p>
<p class="MsoNormal" style="text-align:justify;text-justify:inter-ideograph"><span style="mso-bookmark:_Hlk163812280"><span style="font-size:12.0pt;font-family:"Arial",sans-serif;color:#6A6A6A">Expertise in Structural Biology, cryo-EM/ET, X-ray Crystallography,
and Molecular Dynamic simulations will be a plus but is not required, as this position (NIH-funded for 3-4 years) is an excellent opportunity to learn cryo-EM or expand your existing capabilities.<o:p></o:p></span></span></p>
<p class="MsoNormal" style="text-align:justify;text-justify:inter-ideograph"><span style="mso-bookmark:_Hlk163812280"><span style="font-size:12.0pt;font-family:"Arial",sans-serif;color:#6A6A6A"><o:p> </o:p></span></span></p>
<p class="MsoNormal" style="text-align:justify;text-justify:inter-ideograph"><span style="mso-bookmark:_Hlk163812280"><span style="font-size:12.0pt;font-family:"Arial",sans-serif;color:#6A6A6A">Our
</span></span><a href="https://urldefense.com/v3/__https://www.umassmed.edu/research/cores/cryo-em-core-facility/__;!!Mih3wA!C-j5PYzhpUC9W2IpGHtUTYQqlu225K-3hi5A1Ot0Cx0V276hJG6OHSswdPKjYtVrj_oHI-avw7qA0JXBpY8CaI6Q$"><span style="mso-bookmark:_Hlk163812280"><span style="font-size:12.0pt;font-family:"Arial",sans-serif">UMass Chan Cryo-EM Core Facility</span></span><span style="mso-bookmark:_Hlk163812280"></span></a><span style="mso-bookmark:_Hlk163812280"><span style="font-size:12.0pt;font-family:"Arial",sans-serif;color:#6A6A6A">
is superbly equipped and staffed to carry out this work (Titan Krios, Talos-Arctica, Glacios, with K3 cameras and energy filters, Aquilos FIB-SEM, etc.), and provides excellent hands-on training.<o:p></o:p></span></span></p>
<p class="MsoNormal" style="text-align:justify;text-justify:inter-ideograph"><span style="mso-bookmark:_Hlk163812280"><span style="font-size:12.0pt;font-family:"Arial",sans-serif;color:#6A6A6A"><o:p> </o:p></span></span></p>
<p class="MsoNormal"><span style="mso-bookmark:_Hlk163812280"><span style="font-size:12.0pt;font-family:"Arial",sans-serif">Please send your cover letter and resume to
</span></span><a href="mailto:raul.padron@umassmed.edu"><span style="mso-bookmark:_Hlk163812280"><span style="font-size:12.0pt;font-family:"Arial",sans-serif">raul.padron@umassmed.edu</span></span><span style="mso-bookmark:_Hlk163812280"></span></a><span style="mso-bookmark:_Hlk163812280"><span style="font-size:12.0pt;font-family:"Arial",sans-serif">
and </span></span><a href="mailto:roger.craig@umassmed.edu"><span style="mso-bookmark:_Hlk163812280"><span style="font-size:12.0pt;font-family:"Arial",sans-serif">roger.craig@umassmed.edu</span></span><span style="mso-bookmark:_Hlk163812280"></span></a><span style="mso-bookmark:_Hlk163812280"></span></p>
<p class="MsoNormal"><span style="mso-bookmark:_Hlk163812280"><span style="font-size:12.0pt;font-family:"Arial",sans-serif"><o:p> </o:p></span></span></p>
<p class="MsoNormal"><span style="mso-bookmark:_Hlk163812280"><span style="font-size:12.0pt;font-family:"Arial",sans-serif">All the best,<o:p></o:p></span></span></p>
<p class="MsoNormal"><span style="mso-bookmark:_Hlk163812280"><span style="font-size:12.0pt;font-family:"Arial",sans-serif"><o:p> </o:p></span></span></p>
<p class="MsoNormal"><span style="mso-bookmark:_Hlk163812280"><span style="font-size:12.0pt;font-family:"Arial",sans-serif">Raul Padron & Roger Craig</span></span><span style="font-size:12.0pt;font-family:"Arial",sans-serif"><o:p></o:p></span></p>
<p class="MsoNormal"><o:p> </o:p></p>
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