[3dem] Postdoctoral position in Structural Biology of Dynamic Membrane Pores

[Tobias Raisch]

A fully funded postdoctoral position is available in the project group of Dr. Tobias Raisch in the Department of Structural Biochemistry (Director: Prof. Stefan Raunser) at the Max Planck Institute of Molecular Physiology in Dortmund, Germany. The position is available from November 2023 onwards and is initially limited to 3 years. The successful candidate will work in a dynamic international team situated in a world-renowned institute with cutting-edge infrastructure for cryo-EM and cryo-ET.


Summary:

The goal of the project is to understand the structural architecture and dynamic assembly of a eukaryotic pore-forming membrane attack complex that induces cell death. We aim to determine high-resolution structures of reconstituted pores in vitro from purified components as well as to visualize the pore arrangement in situ in its native membrane. To this end, a combination of methods including membrane complex reconstitution and isolation, single particle electron cryo-microscopy (cryo-EM), cryogenic focused ion beam (cryo-FIB) milling and electron cryo-tomography (cryo-ET) will be applied. The candidate will be part of a multidisciplinary research team involving researchers at MPI Dortmund and University of Geneva (Switzerland) that is funded by a SINERGIA grant of the Swiss National Fund (SNF) and aims at integrating multi-scale data to visualize the dynamic assembly and growth of medically highly important membrane pores.

The group of Tobias Raisch combines biochemical reconstitution and characterization with in vitro and in situ structural elucidation of medically relevant membrane proteins and membrane protein complexes in order to understand their function and dynamic mechanism. The Department of Structural Biochemistry is on the forefront of cryo-EM and cryo-ET, with expertise ranging from method development to applying electron microscopy techniques to challenging biological systems.
More information on the Raisch group: https://urldefense.com/v3/__https://www.mpi-dortmund.mpg.de/4347197/raisch__;!!Mih3wA!G0BWKwyOQlJOBWyQN390-dirAnGVJKmGKccdkhJuz1GhCfqJLhCgIQ3RMva-yd8cd48OcJP2kg6ZsbdlHQuTnh-R$  [https://urldefense.com/v3/__https://www.mpi-dortmund.mpg.de/4347197/raisch__;!!Mih3wA!G0BWKwyOQlJOBWyQN390-dirAnGVJKmGKccdkhJuz1GhCfqJLhCgIQ3RMva-yd8cd48OcJP2kg6ZsbdlHQuTnh-R$ ]

Requirements:
Ideal candidates should hold an excellent PhD in structural biology, biochemistry, biophysics or in an equivalent area. Experience in membrane protein biochemistry, single particle cryo-EM or cryo-ET is an asset, curiosity and willingness to learn new methods and adjust to technological developments a must.

Strong written and oral communication skills in English as well as ability to work independently and in a collaborative project with multiple scientists from diverse backgrounds are required.

Why join us?
Being a part of the community at the Max Planck Institute is more than just a job. Our dynamic research environment, distinct culture, and diverse community foster collaboration and excellence in every corner of science. We offer an extensive range of benefits and resources such as:
* access to state-of-the-art research facilities
* opportunities to collaborate on cutting-edge research
* an international and exciting working atmosphere
* an integrated training program that includes lectures, advanced scientific workshops, complementary skill courses and opportunities for career development
* a mentoring program to guide and promote young scientists

Salary:
Payment depends on personal conditions and qualification according to the directive of the TVöD. Social benefits correspond to those of the public service.
 
How to Apply:
Applicants should submit a CV, a motivation letter outlining research experiences and interests and two reference letters by September 30th, 2023 to Tobias Raisch at tobias.raisch at mpi-dortmund.mpg.de
 
Additional Information:
The Max Planck Society (Max Planck Gesellschaft – MPG) is committed to increasing the number of individuals with disabilities in its workforce and therefore encourages applications from such qualified individuals.

The MPG seeks to increase the number of women in those areas where they are underrepresented and therefore explicitly encourages women to apply.

Furthermore, the MPG strives to foster an inclusive culture and diversity within its workforce. Therefore, all qualified applicants are encouraged to apply and will receive consideration for employment without regard to ethnicity, religion, skin color, national origin, age, sex, sexual orientation, disability status, or any other characteristic protected by applicable law.




Dr. Tobias Raisch (he/him)
Project Group Leader - Structural Biochemistry of Membrane Proteins

Max Planck Institute of Molecular Physiology
Department of Structural Biochemistry
Tel: +49 (231) 133-2315
Otto-Hahn-Str. 11
D-44227 Dortmund
Germany

tobias.raisch at mpi-dortmund.mpg.de [mailto:tobias.raisch at mpi-dortmund.mpg.de]
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