[3dem] Ph.D. position in CryoEM of bacteriophages

[Per A Bullough]

We have a Ph.D. studentship available in structure and function of
bacteriophages. Applications will be considered from eligible students of
any nationality.



White Rose BBSRC DTP: Deciphering the structural and genetic intricacies of
bacteriophage interaction with an AMR pathogen


University of Sheffield - White Rose BBSRC Doctoral Training Partnership


PhD Research Project


Directly Funded


Supervisors: Prof G Stafford,  Prof P A Bullough,  Dr S Mesnage,  Dr J
Rafferty



Application Deadline: 07 January 2024



Details


Bacteriophage are the most numerous biological entities on our planet; they
are viruses that have evolved to exquisitely target bacterial pathogens
with which they have co-evolved. This project aims to use a combined
structural (Cryo-EM, electron tomography), biochemical (enzymology),
microbiological (phage infections, AMR assays) and genetic approaches
(variant sequencing) to uncover the mechanisms occurring at the bacterial
cell surface during phage killing of the multiply drug-resistant
pathogen *Enterococcus
faecium*. The work will uncover the fundamental mechanisms at work at this
cross-kingdom viral-bacterial interface and help to pave the way towards
the realization of bacteriophage based therapies to treat incurable
drug-resistant infections.


You will join a thriving microbiology and structural biology community in
Sheffield focussing on AMR pathogens and bacteriophage and join a
supportive and stimulating intellectual environment. This project will
provide a broad training in phage biology, structural biology as well as
basic bioinformatics.


The University of Sheffield and the DTP provides bespoke training
programmes and has the highest standards of equality and diversity
programmes with its One University pillar.


What is on offer?


This is a core studentship for entry in October 2024.


Join us and you will receive a 4-year, funded PhD programme of research and
skills training, with cross-disciplinary supervision, plus a structured
programme of cohort-wide training and networking events. A highlight is the
annual symposium, which is planned and delivered by students.


A unique part of your training will be the Professional Internships for PhD
Students (PIPS), where you will spend three months at a host organisation
of your choosing, gaining experience of work in a professional environment,
and acquiring transferable skills that will be beneficial in your future
career.


How to apply –


follow this link
https://urldefense.com/v3/__https://www.whiterose-mechanisticbiology-dtp.ac.uk/standard-studentships-2/__;!!Mih3wA!BlnZ5zfe-TXUexSIGjIqSy9hbwDeZWWlMp6ML__E2_RF6QjTSR3kn1CgTtSFmwH88wgnBkF0iG5eSJI3u_jtEgDSpEcLgw$ 


Deadline is midnight Sunday 7th January 2024.


For informal enquiries, please contact Prof. Per Bullough
p.bullough at sheffield.ac.uk.

Prof. Per A. Bullough
Harrison Chair of Structural Biology
Lead, Molecular Microbiology; Biochemistry to Disease
School of Biosciences
University of Sheffield
Firth Court
Western Bank
Sheffield S10 2TN
United Kingdom

Tel:      +44 (0)114 222 4245
Fax:      +44 (0)114 222 2800
e-mail:   p.bullough at sheffield.ac.uk <p.bullough at sheffield.ac.uk>
https://urldefense.com/v3/__https://www.sheffield.ac.uk/biosciences/research/areas/molecular-microbiology__;!!Mih3wA!BlnZ5zfe-TXUexSIGjIqSy9hbwDeZWWlMp6ML__E2_RF6QjTSR3kn1CgTtSFmwH88wgnBkF0iG5eSJI3u_jtEgB6cpPfAQ$ 
https://urldefense.com/v3/__https://www.sheffield.ac.uk/biosciences/people/academic-staff/bullough__;!!Mih3wA!BlnZ5zfe-TXUexSIGjIqSy9hbwDeZWWlMp6ML__E2_RF6QjTSR3kn1CgTtSFmwH88wgnBkF0iG5eSJI3u_jtEgCg82t1IQ$ 
https://urldefense.com/v3/__http://www.floreyinstitute.com/__;!!Mih3wA!BlnZ5zfe-TXUexSIGjIqSy9hbwDeZWWlMp6ML__E2_RF6QjTSR3kn1CgTtSFmwH88wgnBkF0iG5eSJI3u_jtEgDRpL0Tnw$ 
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