[3dem] Seeking advice for RELION cryo-EM workstation

[Guillaume Gaullier]

Hi Alicia,

60 TB of bulk storage (maybe less usable space, depending on the raid configuration of these HDD) will be barely sufficient for working on one dataset at a time. Storage is the most overlooked of the configuration options (we are all obsessed with computing power, GPUs, etc.), but insufficient storage will be an endless source of problems and frustration down the road (speaking from experience…). You will be wasting GPU time if a significant fraction of the time is spent moving data around because the workstation’s bulk storage is full.

So you should plan for this before buying, and my main recommendation is to get as much bulk storage as you can afford.

I hope this helps,

Guillaume


On 3 Oct 2023, at 23:18, Yingxia Hu <yhu at hexagonbio.com<mailto:yhu at hexagonbio.com>> wrote:

Dear colleagues,

I am seeking advice on building a cryo-EM workstation for data processing using RELION. Here is a draft configuration:

  *   1x Intel Xeon W Series CPU, 12 cores, 3.20 GHz;
  *   8x32GB RAM;
  *   1TB M2 drive for OS, 3.84TB U.2 NVMe drive for scratch disk;
  *   3x20TB Hard Drive (3.5" Internal - SATA/600 - 7200rpm);
  *   2x Nvidia RTX A4500.

Would 2x A4500 be sufficient for RELION jobs? And which one would be better between 4070 (12GB memory, faster clock speed) and A4500 (20GB, slower clock speed)? Any other advice is appreciated. Thanks in advance!

Best,
Alicia


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