[3dem] Senior Scientist position available in Structural Biology within SANOFI (Cambridge Massachusetts)

[eduardo Bruch]

Dear all,



Our Structural Biology group within SANOFI (Cambridge Massachusetts) has an
opening for a Senior Scientist (Job ID: R2695834) and we are seeking a
highly motivated scientist with a solid background in structural biology
and strong hands-on experience in CryoEM.



If you are interested in applying for this position, please follow the link
provided below.



Thanks in advance for your interest!

Best

Eduardo Bruch



https://urldefense.com/v3/__https://sanofi.wd3.myworkdayjobs.com/SanofiCareers/job/Cambridge-MA/Senior-Scientist_R2695834__;!!Mih3wA!DeqYJlhkgWpS4eOMm53ADWqb_R9H5bIE3Vai6ZYNeihyufV3bVAuB2NKgH3TwYPcS-l49SoewesBp8wTnKVPZ7blPl2ALg$ 



Senior. Scientist - U.S. IDD structural biology

We are looking for a highly motivated scientist to join our structural
biology group at Sanofi in Cambridge MA.  As a key member of our dynamic
team, you will be responsible for determining critical structural biology
data through both cryo-electron microscopy and x-ray crystallography;
actively pursuing solutions for unmet medical needs in diverse therapeutic
areas and collaborating with multidisciplinary teams within Sanofi in
Cambridge, US, Frankfurt, Germany and Paris, France. The successful
candidate will excel in a fast-paced, highly diverse discovery environment,
will have a strong focus on scientific rigor, have proven success in
organized and independent work, and an exceptional attention to detail.
Applicants who are passionate about structural biology are encouraged to
apply.

Candidate profile:

·       CryoEM expert scientist that can independently design and carry out
EM experiments and interpret results (sample preparation, data collection,
data processing and solving structures). Analyze interactions and propose
structure-based improvements for small-molecule drug discovery. Enable
building state-of-the art technologies in related areas to enhance research
activities.

·       Work closely with Sanofi digital to automate CryoEM data collection
processes to evaluate samples in medium-throughput manner. Python or other
programming languages for building pipelines for data collection and
processing is a plus.

·       Share responsibility for maintaining the Glacios cryo-electron
microscope (beam alignment, calibration, cryo-cycling, etc.).

·       Expertise with all related softwares (CryoSparc, SerialEM, Relion,
cisTEM, Chimera, Eman2, Coot, phenix, ccp4 suite etc.).

·       Provide expertise to project teams pursuing different drug
modalities at Sanofi.

·       Manage and deliver on projects in a timely fashion.

·       Train new users on finer aspects of CryoEM grid preparation and
data collection when necessary.

·       Experience in X-ray crystallography is a strong plus. The candidate
will be expected to train to support this area in case of no prior
experience.

·       Experience in expression and purification strategies using
bacterial, insect, and mammalian hosts and membrane protein purification.
The candidate should be capable of purifying protein for the structural
biology group when needed.

·       Experience in biophysical characterization (SPR, DSF, MST etc.) is
a plus.

·       Have excellent communication skills. Should be able to clearly
articulate data, project strategies both internally and externally.

Qualifications:

·       PhD with 3+yrs of postdoctoral and/or industry experience in
Structural Biology, Biophysics, Protein Biochemistry or related discipline.

·       Strong experience in cryo-EM is required.

·       The ideal candidate should be detail-oriented, organized and
demonstrate good lab practices.

·       Must be a collaborative team player with strong communication
skills.

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative
Action employers committed to a culturally diverse workforce. All qualified
applicants will receive consideration for employment without regard to
race; color; creed; religion; national origin; age; ancestry; nationality;
marital, domestic partnership or civil union status; sex, gender, gender
identity or expression; affectional or sexual orientation; disability;
veteran or military status or liability for military status; domestic
violence victim status; atypical cellular or blood trait; genetic
information (including the refusal to submit to genetic testing) or any
other characteristic protected by law.

As a healthcare company and a vaccine manufacturer, Sanofi has an important
responsibility to protect individual and public health. All US based roles
require individuals to be fully vaccinated against COVID-19 as part of your
job responsibilities.

According to the CDC, an individual is considered to be “fully vaccinated”
fourteen (14) days after receiving (a) the second dose of the Moderna or
Pfizer vaccine, or (b) the single dose of the J&J vaccine. Fully
vaccinated, for new Sanofi employees, is to be fully vaccinated 14 DAYS
PRIOR TO START DATE.

#GD-SA
#LI-SA

At Sanofi diversity and inclusion is foundational to how we operate and
embedded in our Core Values. We recognize to truly tap into the richness
diversity brings we must lead with inclusion and have a workplace where
those differences can thrive and be leveraged to empower the lives of our
colleagues, patients and customers. We respect and celebrate the diversity
of our people, their backgrounds and experiences and provide equal
opportunity for all.
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