[3dem] Postdoctoral positions available

[Olsen, Shaun K]

Dear Colleagues,

A postdoctoral position is immediately available for a highly motivated individual interested in elucidating molecular mechanisms of ubiquitin signaling and DNA repair.  Research is focused on the enzymatic machinery responsible for protein ubiquitination and large protein complexes involved in regulating DNA repair and immunity.  These issues will be addressed using a multidisciplinary approach that includes cryo-EM and X-ray crystallography, complemented with biochemical/biophysical techniques and cell-based assays.

Successful candidates will join the vibrant scientific community at UT Health San Antonio and enjoy abundant access to state-of-the-art cryo-EM instrumentation including a Glacios TEM equipped with a Falcon 4 direct electron detector and Selectris Imaging Filter that are the centerpiece of our brand new cryo-EM facility.  Access to outstanding X-ray crystallography and NMR resources are also available.

Candidates should hold a recently obtained PhD in biochemistry, chemistry, or related subject.  Demonstrated expertise in cryo-EM is highly desirable, though individuals with expertise in protein chemistry, and/or the biochemical analysis of protein ubiquitination and/or DNA repair will also be considered.  Experience with protein expression in insect and mammalian cells is a plus.

Recent publications highlighting our research interests:
*Structural insights into BCDX2 complex function in homologous recombination [https://urldefense.com/v3/__https://www.nature.com/articles/s41586-023-06219-w__;!!Mih3wA!GLojFxnuCtbjW970BjtM9LTPjNLKKv0lexV3FMND1y81xWeLDwML_9N4trvxKBfGhOWn_4FFvZwNgPkS4LVr$ ]
*Cryo-EM structures of Uba7 reveal the molecular basis for ISG15 activation and E1-E2 thioester transfer [https://urldefense.com/v3/__https://www.nature.com/articles/s41467-023-39780-z__;!!Mih3wA!GLojFxnuCtbjW970BjtM9LTPjNLKKv0lexV3FMND1y81xWeLDwML_9N4trvxKBfGhOWn_4FFvZwNgEJ_JGrY$ ]
*Crystal structures reveal catalytic and regulatory mechanisms of the dual-specificity ubiquitin/FAT10 E1 enzyme Uba6 [https://urldefense.com/v3/__https://www.nature.com/articles/s41467-022-32613-5__;!!Mih3wA!GLojFxnuCtbjW970BjtM9LTPjNLKKv0lexV3FMND1y81xWeLDwML_9N4trvxKBfGhOWn_4FFvZwNgJ9jVOCr$ ]
*Activity profiling and crystal structures of inhibitor-bound SARS-CoV-2 papain-like protease: A framework for anti-COVID-19 drug design [https://urldefense.com/v3/__https://www.science.org/doi/10.1126/sciadv.abd4596__;!!Mih3wA!GLojFxnuCtbjW970BjtM9LTPjNLKKv0lexV3FMND1y81xWeLDwML_9N4trvxKBfGhOWn_4FFvZwNgBwTX9p4$ ]

Interested candidates should e-mail a cover letter, CV, and the names of three references to: olsens at uthscsa.edu<mailto:olsens at uthscsa.edu>.

Best,

-Shaun

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Shaun K. Olsen, Ph.D.
Associate Professor
CPRIT Scholar
Department of Biochemistry & Structural Biology
University of Texas Health Science Center at San Antonio
7703 Floyd Curl Drive, BSB413C/414C
San Antonio, Texas 78229-3900
Lab: 210-450-8681

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