[3dem] Integrative Structural Biology Postdoc Positions

Tue Oct 25 18:25:55 PDT 2022

Dear all,

I would like to draw your attention to open postdoctoral researcher positions in my group. We use a diverse set of model systems to study how cell surfaces are engineered to support diverse physiological processes, including tissue homeostasis, cell wall formation, microbial encapsulation, and biofilm formation. Our work integrates molecular and glycobiology techniques with cryo electron microscopy and crystallography. These classical efforts are complemented with MINFLUX super-resolution nanoscopy and cryo electron tomography, providing insights into the cellular locations, assemblies, and dynamics of membrane-embedded polysaccharide secretion machineries. Representative publications can be found below.

Candidates should have a strong background in molecular biology and/or structural biology techniques, be enthusiastic about working in a diverse, multidisciplinary research environment, and have at least one per-reviewed first author publication.

We are located in Charlottesville, Virginia, about 100 miles from Washington DC, 70 miles from Richmond, and just 25 miles to the Shenandoah National Park.

Interested candidates should contact me via email (jz3x at virginia.edu<mailto:jz3x at virginia.edu>) or apply directly via: https://urldefense.com/v3/__https://hhmi.wd1.myworkdayjobs.com/External/job/University-of-Virginia/Postdoctoral-Associate---Zimmer-Lab_R-1271__;!!Mih3wA!DvW3vL6-2D6tfS9KCLdAcg7hfBV-gl-eJTuCz42qHrNBJuFzs8NchfPMjIDxyHhvZWLt8WIwnhUTKtoUuRo$  .

Sincerely,

Jochen

+++++++++

Molecular basis for polysaccharide recognition and modulated ATP hydrolysis by the O antigen ABC transporter. <https://urldefense.com/v3/__https://pubmed.ncbi.nlm.nih.gov/36064941/__;!!Mih3wA!DvW3vL6-2D6tfS9KCLdAcg7hfBV-gl-eJTuCz42qHrNBJuFzs8NchfPMjIDxyHhvZWLt8WIwnhUT2GLBIDE$  > Spellmon N, Muszyński A, Górniak I, Vlach J, Hahn D, Azadi P, Zimmer J. Nat Commun. 2022 Sep 5;13(1):5226

Structure, substrate recognition and initiation of hyaluronan synthase. <https://urldefense.com/v3/__https://pubmed.ncbi.nlm.nih.gov/35355017/__;!!Mih3wA!DvW3vL6-2D6tfS9KCLdAcg7hfBV-gl-eJTuCz42qHrNBJuFzs8NchfPMjIDxyHhvZWLt8WIwnhUTSlzAx94$  > Maloney FP, Kuklewicz J, Corey RA, Bi Y, Ho R, Mateusiak L, Pardon E, Steyaert J, Stansfeld PJ, Zimmer J. Nature. 2022 Apr;604(7904):195-201

Molecular organization of the E. coli cellulose synthase macrocomplex. <https://urldefense.com/v3/__https://pubmed.ncbi.nlm.nih.gov/33712813/__;!!Mih3wA!DvW3vL6-2D6tfS9KCLdAcg7hfBV-gl-eJTuCz42qHrNBJuFzs8NchfPMjIDxyHhvZWLt8WIwnhUT60F_dLw$  > Acheson JF, Ho R, Goularte NF, Cegelski L, Zimmer J. Nat Struct Mol Biol. 2021 Mar;28(3):310-318

Architecture of a catalytically active homotrimeric plant cellulose synthase complex. <https://urldefense.com/v3/__https://pubmed.ncbi.nlm.nih.gov/32646917/__;!!Mih3wA!DvW3vL6-2D6tfS9KCLdAcg7hfBV-gl-eJTuCz42qHrNBJuFzs8NchfPMjIDxyHhvZWLt8WIwnhUTIeniOPw$  > Purushotham P, Ho R, Zimmer J. Science. 2020 Aug 28;369(6507):1089-1094

Architecture of a channel-forming O-antigen polysaccharide ABC transporter. <https://urldefense.com/v3/__https://pubmed.ncbi.nlm.nih.gov/29320481/__;!!Mih3wA!DvW3vL6-2D6tfS9KCLdAcg7hfBV-gl-eJTuCz42qHrNBJuFzs8NchfPMjIDxyHhvZWLt8WIwnhUTd3-XPfg$  > Bi Y, Mann E, Whitfield C, Zimmer J. Nature. 2018 Jan 18;553(7688):361-365

Observing cellulose biosynthesis and membrane translocation in crystallo. <https://urldefense.com/v3/__https://pubmed.ncbi.nlm.nih.gov/26958837/__;!!Mih3wA!DvW3vL6-2D6tfS9KCLdAcg7hfBV-gl-eJTuCz42qHrNBJuFzs8NchfPMjIDxyHhvZWLt8WIwnhUTYvnY5SE$  > Morgan JL, McNamara JT, Fischer M, Rich J, Chen HM, Withers SG, Zimmer J. Nature. 2016 Mar 17;531(7594):329-34

*******************************

Jochen Zimmer, D. Phil.

Investigator, Howard Hughes Medical Institute

University of Virginia

Molecular Physiology & Biol. Physics

480 Ray C. Hunt Dr.

Snyder Bldg. #380

Charlottesville, VA 22908, USA

Phone: +1 434 243 6506

https://urldefense.com/v3/__https://jochenzimmer.faculty.virginia.edu/__;!!Mih3wA!DvW3vL6-2D6tfS9KCLdAcg7hfBV-gl-eJTuCz42qHrNBJuFzs8NchfPMjIDxyHhvZWLt8WIwnhUTze5R8gQ$  
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