[3dem] Two challenging Postdoc positions in cryo-EM/muscle structural biology –UMass Chan Medical School (Padron-Craig lab)

[Raul Padron]

Dear all,

We are looking for two highly motivated, dynamic and driven postdocs to join our cryo-EM muscle structural biology team at the Division of Cell Biology and Imaging, UMass Chan Medical School in Worcester, MA. The Padron/Craig lab<https://urldefense.com/v3/__https://www.umassmed.edu/padron-craig/__;!!Mih3wA!DdEdubf-1YAWFr7PgTgdqw_0-KL2ZuL8VkFfSsIcd-Gviw3GQRsDmwjv62_FDoSkvOfDIFOGmwOj3vfJK3reSvdK$  > has focused on the structure of myosin molecules and muscle thick filaments since discovering the myosin interacting-heads motif (IHM) in filaments by cryo-EM in 2005 (Woodhead et al Nature 436, 1195-1199<https://urldefense.com/v3/__https://www.nature.com/articles/nature03920__;!!Mih3wA!DdEdubf-1YAWFr7PgTgdqw_0-KL2ZuL8VkFfSsIcd-Gviw3GQRsDmwjv62_FDoSkvOfDIFOGmwOj3vfJK5umlpd2$  >), leading to the recently published 4.3 Å resolution structure of the myosin II molecule in the inhibited state (Yang et al., Nature 588, 521-525<https://urldefense.com/v3/__https://www.nature.com/articles/s41586-020-3007-0__;!!Mih3wA!DdEdubf-1YAWFr7PgTgdqw_0-KL2ZuL8VkFfSsIcd-Gviw3GQRsDmwjv62_FDoSkvOfDIFOGmwOj3vfJK_Yag5E9$  >). Ideal candidates to join this adventure, solving the near-atomic cryo-EM structure of the IHM in situ, with implications for muscle relaxation and activation, muscle disease, and drug treatment, will possess a broad curiosity and a passion for discovery. Having expertise in cryo-EM/ET or X-ray crystallography will be a plus but is not required, as these positions (NIH-funded for 4-5 years) are an excellent opportunity as well to learn cryo-EM or expand your existing cryo-EM capabilities. Our cryo-EM Core<https://urldefense.com/v3/__https://www.umassmed.edu/research/cores/cryo-em-core-facility/__;!!Mih3wA!DdEdubf-1YAWFr7PgTgdqw_0-KL2ZuL8VkFfSsIcd-Gviw3GQRsDmwjv62_FDoSkvOfDIFOGmwOj3vfJK4jmzfry$  > is superbly equipped and staffed to carry out this work (Titan Krios, Talos-Arctica, Glacios, with K3 cameras and energy filters, Aquilos FIB-SEM, etc.) and to provide excellent hands-on training.

For further information, please send cover letter, current CV and the names and contact information of three references to: Raul Padron (raul.padron at umassmed.edu<mailto:raul.padron at umassmed.edu>) and Roger Craig (roger.craig at umassmed.edu<mailto:roger.craig at umassmed.edu>).

All the best,

Raul Padron & Roger Craig

Raúl Padrón Ph.D.
Professor. Division of Cell Biology and Imaging, Department of Radiology, Rm. S7-212,
UMass Chan Medical School, 55 Lake Ave. North, Worcester, MA 01655, USA.
Phone +1 (508) 856 1675  - Email: raul.padron at umassmed.edu<mailto:raul.padron at umassmed.edu>
Padrón-Craig Lab web page<https://urldefense.com/v3/__https://www.umassmed.edu/padron-craig/__;!!Mih3wA!DdEdubf-1YAWFr7PgTgdqw_0-KL2ZuL8VkFfSsIcd-Gviw3GQRsDmwjv62_FDoSkvOfDIFOGmwOj3vfJK3reSvdK$  >     Raúl Padrón UMass Chan Profile<https://urldefense.com/v3/__https://profiles.umassmed.edu/display/22222598__;!!Mih3wA!DdEdubf-1YAWFr7PgTgdqw_0-KL2ZuL8VkFfSsIcd-Gviw3GQRsDmwjv62_FDoSkvOfDIFOGmwOj3vfJK3NdK3L3$  >





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