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<p class="MsoNormal">Dear all,</p>
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<p class="MsoNormal">We are looking for two highly motivated, dynamic and driven postdocs to join our cryo-EM muscle structural biology team at the Division of Cell Biology and Imaging, UMass Chan Medical School in Worcester, MA. The
<a href="https://urldefense.com/v3/__https://www.umassmed.edu/padron-craig/__;!!Mih3wA!DdEdubf-1YAWFr7PgTgdqw_0-KL2ZuL8VkFfSsIcd-Gviw3GQRsDmwjv62_FDoSkvOfDIFOGmwOj3vfJK3reSvdK$">Padron/Craig lab</a> has focused on the structure of myosin molecules and muscle thick filaments since discovering the myosin interacting-heads motif (IHM) in filaments by cryo-EM in 2005 (<a href="https://urldefense.com/v3/__https://www.nature.com/articles/nature03920__;!!Mih3wA!DdEdubf-1YAWFr7PgTgdqw_0-KL2ZuL8VkFfSsIcd-Gviw3GQRsDmwjv62_FDoSkvOfDIFOGmwOj3vfJK5umlpd2$">Woodhead
et al Nature 436, 1195-1199</a>), leading to the recently published 4.3 Å resolution structure of the myosin II molecule in the inhibited state (<a href="https://urldefense.com/v3/__https://www.nature.com/articles/s41586-020-3007-0__;!!Mih3wA!DdEdubf-1YAWFr7PgTgdqw_0-KL2ZuL8VkFfSsIcd-Gviw3GQRsDmwjv62_FDoSkvOfDIFOGmwOj3vfJK_Yag5E9$">Yang et al., Nature 588, 521-525</a>). Ideal candidates
to join this adventure, solving the near-atomic cryo-EM structure of the IHM in situ, with implications for muscle relaxation and activation, muscle disease, and drug treatment, will possess a broad curiosity and a passion for discovery. Having expertise in
cryo-EM/ET or X-ray crystallography will be a plus but is not required, as these positions (NIH-funded for 4-5 years) are an excellent opportunity as well to learn cryo-EM or expand your existing cryo-EM capabilities. Our
<a href="https://urldefense.com/v3/__https://www.umassmed.edu/research/cores/cryo-em-core-facility/__;!!Mih3wA!DdEdubf-1YAWFr7PgTgdqw_0-KL2ZuL8VkFfSsIcd-Gviw3GQRsDmwjv62_FDoSkvOfDIFOGmwOj3vfJK4jmzfry$">cryo-EM Core</a> is superbly equipped and staffed to carry out this work (Titan Krios, Talos-Arctica, Glacios, with K3 cameras and energy filters, Aquilos FIB-SEM, etc.) and to provide
excellent hands-on training.</p>
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<p class="MsoNormal">For further information, please send cover letter, current CV and the names and contact information of three references to: Raul Padron (<a href="mailto:raul.padron@umassmed.edu">raul.padron@umassmed.edu</a>) and Roger Craig (<a href="mailto:roger.craig@umassmed.edu">roger.craig@umassmed.edu</a>).</p>
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<p class="MsoNormal">All the best,</p>
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<p class="MsoNormal">Raul Padron & Roger Craig</p>
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<p style="margin-bottom:0in;background:white"><span style="font-size:7.5pt;font-family:"Comic Sans MS";color:black">Raúl Padrón Ph.D.</span><span style="font-size:12.0pt;font-family:"Arial",sans-serif;color:#222222"><o:p></o:p></span></p>
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<p class="MsoNormal" style="background:white"><span style="font-size:7.5pt;font-family:"Comic Sans MS";color:black">Professor. Division of Cell Biology and Imaging, Department of Radiology, Rm. S7-212, </span><span style="font-size:12.0pt;font-family:"Arial",sans-serif;color:#222222"><o:p></o:p></span></p>
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<p class="MsoNormal" style="background:white"><span style="font-size:7.5pt;font-family:"Comic Sans MS";color:black">UMass Chan Medical School, 55 Lake Ave. North, Worcester, MA 01655, USA. </span><span style="font-size:12.0pt;font-family:"Arial",sans-serif;color:#222222"><o:p></o:p></span></p>
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<p class="MsoNormal" style="background:white"><span style="font-size:7.5pt;font-family:"Comic Sans MS";color:black">Phone +1 (508) 856 1675 - </span><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#222222">Email: <a href="mailto:raul.padron@umassmed.edu" target="_blank"><span style="color:#1155CC">raul.padron@umassmed.edu</span></a></span><span style="font-size:12.0pt;font-family:"Arial",sans-serif;color:#222222"><o:p></o:p></span></p>
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<p class="MsoNormal" style="background:white"><span style="font-size:7.5pt;font-family:"Arial",sans-serif;color:#222222"><a href="https://urldefense.com/v3/__https://www.umassmed.edu/padron-craig/__;!!Mih3wA!DdEdubf-1YAWFr7PgTgdqw_0-KL2ZuL8VkFfSsIcd-Gviw3GQRsDmwjv62_FDoSkvOfDIFOGmwOj3vfJK3reSvdK$" target="_blank"><span style="color:#1155CC">Padrón-Craig Lab web page</span></a> </span><span style="font-size:12.0pt;font-family:"Arial",sans-serif;color:#222222"><a href="https://urldefense.com/v3/__https://profiles.umassmed.edu/display/22222598__;!!Mih3wA!DdEdubf-1YAWFr7PgTgdqw_0-KL2ZuL8VkFfSsIcd-Gviw3GQRsDmwjv62_FDoSkvOfDIFOGmwOj3vfJK3NdK3L3$" target="_blank"><span style="font-size:10.0pt;color:#1155CC">Raúl
Padrón UMass Chan Profile</span></a><o:p></o:p></span></p>
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