[3dem] Postdoc position at IECB, Bordeaux, France

Pierre Maisonneuve p.maisonneuve at iecb.u-bordeaux.fr
Fri Apr 29 08:25:28 PDT 2022

Dear colleagues, 
We have an open position for a highly motivated postdoctoral candidate in my group at the European Institute of Chemistry and Biology (IECB) to investigate the structural basis of the regulation protein kinases and pseudokinases receptors in human signaling by using cryo-EM. 
Applicants must have a Ph.D. (or due to complete within 6 months) in biochemistry, biophysics, life science or related fields. We are seeking a person with expertise in protein biochemistry (ideally in membrane protein) and with knowledge in single-particle electron microscopy (cryo-EM). Previous experience in protein expression in eukaryotic cells (insect and human) is preferred but not required.

The position is funded for 2 years, but the candidate is encouraged to apply for additional postdoctoral funding.

The candidate will join an exciting and multidisciplinary scientific environment with on-site access to cutting-edge facilities in cryo-EM (housing a 200kV Arctica equipped with a K2 summit camera and soon to come 200kV Cryo-electron microscope equipped with an energy filter and last generation direct detector), X-Ray crystallography, NMR, Biochemistry, Biophysics, molecular biology and cell biology. The project involved international collaborations with cell biologists for complementary characterization of protein function in cell and in mice.  

Interested applicants should submit a cover letter, CV and contact information of 2 references here:  https://urldefense.proofpoint.com/v2/url?u=https-3A__emploi.cnrs.fr_Offres_CDD_UMR5248-2DPIEMAI-2D001_Default.aspx-3Flang-3DEN&d=DwIFaQ&c=-35OiAkTchMrZOngvJPOeA&r=L7-zyQ-04fFCMRqzLIOnx7H0exGZHwIQe_wMPuY600I&m=gaoyyKZWBAcCsRCb7Hwyn10STVcmp9h1PMqQ-9CEVJ7dOUM8Q9ztn5Y1eyyrVk3g&s=ECQy7kvaB9NMcUH4_COW7dFh13Qm5FyMznr44UPFDXM&e=  <https://urldefense.proofpoint.com/v2/url?u=https-3A__emploi.cnrs.fr_Offres_CDD_UMR5248-2DPIEMAI-2D001_Default.aspx-3Flang-3DEN&d=DwIFaQ&c=-35OiAkTchMrZOngvJPOeA&r=L7-zyQ-04fFCMRqzLIOnx7H0exGZHwIQe_wMPuY600I&m=gaoyyKZWBAcCsRCb7Hwyn10STVcmp9h1PMqQ-9CEVJ7dOUM8Q9ztn5Y1eyyrVk3g&s=ECQy7kvaB9NMcUH4_COW7dFh13Qm5FyMznr44UPFDXM&e= >
The deadline for the application is May 30th. The starting date for this position is October 1st.

Example of work that we are developing in the lab:
Posternak G*, Tang X*, Maisonneuve P*, Jin T*, Lavoie H* et al., Functional characterization of a PROTAC directed against BRAF mutant V600E. Nature Chemical Biology. 2020 Nov;16(11):1170-1178. *Equal Contribution
Lavoie H*, Sahmi M*, Maisonneuve P* et al., MEK drives BRAF activation through allosteric control of KSR proteins. Nature. 2018 Feb 22;554(7693):549-553. *Equal Contribution



Pierre Maisonneuve Ph.D.

Group Leader
UMR 5248 - Chemistry & Biology of Membranes and Nano-Objects
CNRS - Université de Bordeaux

Institut Européen de Chimie et Biologie
Phone: +33(0)5 40 00 35 88
@: p.maisonneuve at iecb.u-bordeaux.fr <mailto:p.maisonneuve at iecb.u-bordeaux.fr>
2 rue Robert Escarpit, 
33607 Pessac, France
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