[3dem] Postdoc position in Computational Structural Immunology at the NIH

Youkharibache, Philippe (NIH/NCI) [E] philippe.youkharibache at nih.gov
Wed Apr 20 09:51:28 PDT 2022

A post-doctoral position is available in the Cancer Data Science Lab in computational structural biology to study the structure and function of cell surface proteins and engineer optimized chimeric antigen receptor constructs, integrating structural, biophysical and biological constraints.  It is a key position in an interdisciplinary project bridging structural biology (cryoEM, NMR, Xray), computational biology, cell biology and clinical trials.

Chimeric Antigen Receptors (CAR) are the backbone of CAR-T cell therapies (https://urldefense.proofpoint.com/v2/url?u=https-3A__www.cancer.gov_about-2Dcancer_treatment_research_car-2Dt-2Dcells&d=DwIGaQ&c=-35OiAkTchMrZOngvJPOeA&r=L7-zyQ-04fFCMRqzLIOnx7H0exGZHwIQe_wMPuY600I&m=TcOOCuASaHFELSUeUxIH1LzCoycN4-49jw-eceJiZJgr_HiRiKgtSp8NF4CSA5_Q&s=6UTqhm1wgHFaOl28kr2Wzi5hcLvIgg-nzt0NORn6efk&e= ). They are the focus of over 700 clinical studies being conducted worldwide.

Many teams throughout the world are focusing on the optimization of CAR-Ts for the treatment of patients with relapsed/refactory cancers but the vast majority of studies are performed by an empirical trial and error approach.  This project brings together expertise in CAR-T cell biology, structural biology, computational structural modeling and machine learning to develop a rational design approach.

The candidates should hold a Ph.D. degree, have at least one first author publication and have a strong knowledge of protein structure.  Experience in protein modeling, molecular dynamics simulations (Amber, NAMD, CHARMM, Gromacs etc.), and biophysics methods is needed. Artificial Intelligence (Machine learning) experience and/or software development experience are a plus but not required.

To Apply:
Interested individuals should send a cover letter outlining research interests and long-term goals, CV and the names of three references to:
Philippe Youkharibache, Ph.D. philippe.youkharibache at nih.gov<mailto:philippe.youkharibache at nih.gov>

The NIH is dedicated to building a diverse community in its training and employment programs and encourages the application and nomination of qualified women, minorities, and individuals with disabilities. DHHS and NIH are Equal Opportunity Employers.

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