[3dem] Postdoctoral opportunity for structure studies of the insulin analogues - insulin receptor complex by cryo-EM

[Takagi, Yuichiro]

Dear All

Please find the details below for a postdoctoral position in the Weiss/Takagi labs:

All the best

Yuro

Yuichiro H. Takagi, Ph.D.
Associate Professor
Scientific director of cryo-EM
Department of Biochemistry and Molecular Biology
Indiana University School of Medicine
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Postdoctoral opportunity for structure studies of the insulin analogues - insulin receptor complex by cryo-EM at Indiana University School of Medicine, Indianapolis, IN USA

We invite applications for a post-doctoral position, funded by the NIH and Helmsley Charitable Trust, focusing on cryo-EM studies of how insulin analogs bind to the insulin receptor at the laboratory of Dr. Michael A. Weiss at Department of Biochemistry & Molecular Biology, Indiana University School of Medicine (IUSM). This project is in collaboration with the lab of Dr. Yuichiro Takagi at IUSM. Analogs include ultra-stable and glucose-responsive insulin variants of clinical interest – please see our latest publication in this subject: https://urldefense.proofpoint.com/v2/url?u=https-3A__www.pnas.org_doi_10.1073_pnas.2103518118&d=DwIGaQ&c=-35OiAkTchMrZOngvJPOeA&r=L7-zyQ-04fFCMRqzLIOnx7H0exGZHwIQe_wMPuY600I&m=hBRPoO1blQ3NPLqIdOx9fCbAGX51amZddy3_y11849-2mJhlFvWsr1MSj8jI-8Qg&s=pGdtNwOH20H0zoHXAYzH7fpat5nDP6vZo80W5thWgzU&e= 

The Indiana University School of Medicine (IUSM) has an EM Core with 200 kV Glacios cryo-EM with Falcon 4 camera and shared access to a 300 kV Titan Krios G4 with K3 camera, located at Purdue University as part of a regional consortium. The post-doctoral fellow will be part of a multidisciplinary team including synthetic peptide chemists and cell biologists engaged in insulin research with translational application to the improved treatment of diabetes mellitus. A PhD in structural biology or computation protein chemistry is required. Prior experience with cryo-EM is preferred but not required. We will provide an extensive in-house cryo-EM training. IUSM provides a diverse international community and welcomes applications from scientists of diverse backgrounds, cultures, nationalities and genders. Non-US Citizens will require an appropriate Visa for employment in the United State.

If interested, please submit Curriculum Vitae (CV), letter of introduction and names of three referees (including prior or current laboratory mentors) via the link below:

https://urldefense.proofpoint.com/v2/url?u=https-3A__indiana.peopleadmin.com_postings_12738&d=DwIGaQ&c=-35OiAkTchMrZOngvJPOeA&r=L7-zyQ-04fFCMRqzLIOnx7H0exGZHwIQe_wMPuY600I&m=hBRPoO1blQ3NPLqIdOx9fCbAGX51amZddy3_y11849-2mJhlFvWsr1MSj8jI-8Qg&s=4f4cs9PRM_ooscnP3p7vR4XNupSs-dSpUYOlkCoML_o&e= 

If you have any question, please contact Drs. Yuichiro Takagi and Michael A. Weiss, Department of Biochemistry & Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202 (email addresses ytakagi at iu.edu<mailto:ytakagi at iu.edu> and weissma at iu.edu<mailto:weissma at iu.edu>)














Yuichiro H. Takagi, Ph.D.
Associate Professor
Scientific director of cryo-EM
Department of Biochemistry and Molecular Biology
Indiana University School of Medicine
635 Barnhill Drive, Medical Science Building 4003
Indianapolis, IN 46202
Office: (317) 274-2719
Lab: (317) 274-0889
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