[3dem] CryoEM Postdoc in Stroud group UCSF

[Robert Stroud]

Two post-doctoral positions are available in the Stroud lab at the mission bay campus of the University of California San Francisco (UCSF). (https://urldefense.proofpoint.com/v2/url?u=https-3A__msg.ucsf.edu_people_robert-2Dstroud-2Dma-2Dphd&d=DwIFaQ&c=-35OiAkTchMrZOngvJPOeA&r=L7-zyQ-04fFCMRqzLIOnx7H0exGZHwIQe_wMPuY600I&m=Ul2rZ8N3LBesqH1a9Zw1PO0Vmp8PIIjoOv-8sTHmPSk&s=GzfhWDqI3gibzJhF7qoiHuFPlqwf42TDwIjEb0CBpTU&e=  <https://urldefense.proofpoint.com/v2/url?u=https-3A__msg.ucsf.edu_people_robert-2Dstroud-2Dma-2Dphd&d=DwIFaQ&c=-35OiAkTchMrZOngvJPOeA&r=L7-zyQ-04fFCMRqzLIOnx7H0exGZHwIQe_wMPuY600I&m=Ul2rZ8N3LBesqH1a9Zw1PO0Vmp8PIIjoOv-8sTHmPSk&s=GzfhWDqI3gibzJhF7qoiHuFPlqwf42TDwIjEb0CBpTU&e= >). Research is focused on the structure and mechanisms of transmembrane processes, and particularly in this position on the mechanisms of transporters that package neurotransmitters into synaptic vesicles in the nervous system and the brain. These highly regulated transporters provide for ‘quantal release’ in neuronal signaling. They also do not ‘leak’ after fusion of synaptic vesicles with the plasma membrane. Structures are determined by cryo-electron microscopy, and cryo-electron tomography as inroads to defining the structural basis of function. This also involves expression and purification of membrane proteins, or complexes, use of detergents, and nanodiscs, and assays of transport in vesicles and in cells. Example see (https://urldefense.proofpoint.com/v2/url?u=https-3A__www.ncbi.nlm.nih.gov_pubmed_32439795&d=DwIFaQ&c=-35OiAkTchMrZOngvJPOeA&r=L7-zyQ-04fFCMRqzLIOnx7H0exGZHwIQe_wMPuY600I&m=Ul2rZ8N3LBesqH1a9Zw1PO0Vmp8PIIjoOv-8sTHmPSk&s=eaXZEqN1BFOffl7b6CzXlnotGmCIgRZ7nBRzWLq-sSY&e=  <https://urldefense.proofpoint.com/v2/url?u=https-3A__www.ncbi.nlm.nih.gov_pubmed_32439795&d=DwIFaQ&c=-35OiAkTchMrZOngvJPOeA&r=L7-zyQ-04fFCMRqzLIOnx7H0exGZHwIQe_wMPuY600I&m=Ul2rZ8N3LBesqH1a9Zw1PO0Vmp8PIIjoOv-8sTHmPSk&s=eaXZEqN1BFOffl7b6CzXlnotGmCIgRZ7nBRzWLq-sSY&e= >). Experience in cryo-EM structure determination and preparative biochemistry is an advantage. First rate facilities are available in a highly cooperative environment. If interested please send a brief cover letter, CV and contact information for three persons who might provide references to stroud at msg.ucsf.edu <mailto:stroud at msg.ucsf.edu>. 




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