[3dem] Postdoc position in Egelman lab

[Egelman, Edward H (ehe2n)]

A postdoctoral position is now open in the Egelman lab at the University of Virginia. We have been using cryo-EM to study the structure and function of a large range of protein and nucleoprotein polymers. These projects have included type IV pili of pathogenic bacteria and archaea, flagellar filaments, actin, microbial nanowires and archaeal viruses. Some representative recent publications are listed below. A full publication list can be found at https://urldefense.proofpoint.com/v2/url?u=https-3A__egelmanlab.org&d=DwIGaQ&c=-35OiAkTchMrZOngvJPOeA&r=L7-zyQ-04fFCMRqzLIOnx7H0exGZHwIQe_wMPuY600I&m=J-EkZp7NKxoUFw5p_rBRNK8Tdfo7uK-XU2xKkVsvE2g&s=aT6v3nF19GAmG_lvAm0dxeZsUl3V6JsBoapWpu8CPlU&e= . Prior experience in cryo-EM is helpful, but not essential, as candidates who have had experience in structure determination using techniques such as x-ray crystallography or NMR will also be considered.
Facilities at UVA are state-of-the-art, with a Titan Krios equipped with a K3 camera and a Glacios equipped with a Falcon 4 camera. Charlottesville is a rather idyllic community set next to the scenic Blue Ridge Mountains and we are two hours away from Washington, DC. Applicants should write to Ed Egelman, egelman at virginia.edu<mailto:egelman at virginia.edu>, and include a CV and the names and email addresses of three references.

Recent Representative Publications
DiMaio, F., Yu, X., Rensen, E., Krupovic, M., Prangishvili, D. and Egelman, E.H. (2015). A Virus that Infects a Hyperthermophile Encapsidates A-Form DNA, Science 348, 914-7.


Wang, F., Gu, Y., O’Brien, J.P., Yi, S.M., Yalcin, S.E., Srikanth, V., Shen, C., Vu, D., Ing, N.L., Hochbaum, A.I., Egelman, E.H. and Malvankar, N.S. (2019). Structure of Microbial Nanowires Reveals Stacked Hemes that Transport Electrons over Micrometers. Cell 177, 361-369

Wang, F., Cvirkaite-Krupovic, V., Kreutzberger, M.A,B., Su, Z., de Oliveira, G.A.P., Osinski, T., Sherman, N., DiMaio, F., Wall, J.S., Prangishvili, D., Krupovic, M. and Egelman, E.H. (2019). An extensively glycosylated archaeal pilus survives extreme conditions. Nature Microbiology 4, 1401-1410.

Kreutzberger, M.A.B., Ewing, C., Poly, F., Wang, F. and Egelman, E.H. (2020). Atomic structure of the Campylobacter jejuni flagellar filament reveals how 𝝐 Proteobacteria escaped Toll-like receptor 5 surveillance. Proc. Natl. Acad. Sci. U.S.A. 117, 16985-16991.

Wang, F., Baquero, D.P., Beltran, L., Su, Z., Osinski, T., Zheng, W., Prangishvili, D., Krupovic, M. and Egelman, E.H. (2020). Structures of filamentous viruses infecting hyperthermophilic archaea explain DNA stabilization in extreme environments. Proc. Natl. Acad. Sci. U.S.A. 117, 19643-19652.


Zheng, W., Pena, A., Ilangovan, A., Clark, J.N., Frankel, G., Egelman, E.H., and Costa, T.R.D. (2021). Cryoelectron-microscopy structure of the enteropathogenic Escherichia coli type III secretion system EspA filament. Proc. Natl. Acad. Sci. U.S.A. 118.




Edward Egelman
Harrison Distinguished Professor,
Department of Biochemistry and Molecular Genetics
Professor of Molecular Physiology and Biological Physics
University of Virginia
phone: 434-924-8210
fax: 434-924-5069
egelman at virginia.edu<mailto:egelman at virginia.edu>
https://urldefense.proofpoint.com/v2/url?u=https-3A__egelmanlab.org_&d=DwIGaQ&c=-35OiAkTchMrZOngvJPOeA&r=L7-zyQ-04fFCMRqzLIOnx7H0exGZHwIQe_wMPuY600I&m=J-EkZp7NKxoUFw5p_rBRNK8Tdfo7uK-XU2xKkVsvE2g&s=UiOtqX2sIFKnhPiMGV8a2WWj9v-kik1elGweDiGOQr0&e= 

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