<html xmlns:o="urn:schemas-microsoft-com:office:office" xmlns:w="urn:schemas-microsoft-com:office:word" xmlns:m="http://schemas.microsoft.com/office/2004/12/omml" xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv="Content-Type" content="text/html; charset=utf-8">
<meta name="Generator" content="Microsoft Word 15 (filtered medium)">
<style><!--
/* Font Definitions */
@font-face
{font-family:"Cambria Math";
panose-1:2 4 5 3 5 4 6 3 2 4;}
@font-face
{font-family:Calibri;
panose-1:2 15 5 2 2 2 4 3 2 4;}
@font-face
{font-family:"Times New Roman \(Body CS\)";
panose-1:2 11 6 4 2 2 2 2 2 4;}
@font-face
{font-family:"Helvetica Neue";
panose-1:2 0 5 3 0 0 0 2 0 4;}
/* Style Definitions */
p.MsoNormal, li.MsoNormal, div.MsoNormal
{margin:0in;
font-size:12.0pt;
font-family:"Calibri",sans-serif;}
a:link, span.MsoHyperlink
{mso-style-priority:99;
color:#0563C1;
text-decoration:underline;}
span.EmailStyle17
{mso-style-type:personal-compose;
font-family:"Calibri",sans-serif;
color:windowtext;}
span.EndNoteBibliographyChar
{mso-style-name:"EndNote Bibliography Char";
mso-style-link:"EndNote Bibliography";
font-family:"Calibri",sans-serif;}
p.EndNoteBibliography, li.EndNoteBibliography, div.EndNoteBibliography
{mso-style-name:"EndNote Bibliography";
mso-style-link:"EndNote Bibliography Char";
margin:0in;
font-size:12.0pt;
font-family:"Calibri",sans-serif;}
p.p1, li.p1, div.p1
{mso-style-name:p1;
margin-top:0in;
margin-right:0in;
margin-bottom:0in;
margin-left:4.5pt;
line-height:15.0pt;
font-size:10.5pt;
font-family:"Helvetica Neue";
color:black;}
.MsoChpDefault
{mso-style-type:export-only;
font-size:12.0pt;
font-family:"Calibri",sans-serif;}
@page WordSection1
{size:8.5in 11.0in;
margin:1.0in 1.0in 1.0in 1.0in;}
div.WordSection1
{page:WordSection1;}
--></style>
</head>
<body lang="EN-US" link="#0563C1" vlink="#954F72" style="word-wrap:break-word">
<div class="WordSection1">
<p class="MsoNormal" style="text-indent:.5in">A postdoctoral position is now open in the Egelman lab at the University of Virginia. We have been using cryo-EM to study the structure and function of a large range of protein and nucleoprotein polymers. These
projects have included type IV pili of pathogenic bacteria and archaea, flagellar filaments, actin, microbial nanowires and archaeal viruses. Some representative recent publications are listed below. A full publication list can be found at
<a href="https://urldefense.proofpoint.com/v2/url?u=https-3A__egelmanlab.org&d=DwMGaQ&c=-35OiAkTchMrZOngvJPOeA&r=L7-zyQ-04fFCMRqzLIOnx7H0exGZHwIQe_wMPuY600I&m=J-EkZp7NKxoUFw5p_rBRNK8Tdfo7uK-XU2xKkVsvE2g&s=aT6v3nF19GAmG_lvAm0dxeZsUl3V6JsBoapWpu8CPlU&e=">https://egelmanlab.org</a>. Prior experience in cryo-EM is helpful, but not essential, as candidates who have had experience in structure determination using techniques such as x-ray crystallography or NMR will also be considered.
<o:p></o:p></p>
<p class="MsoNormal" style="text-indent:.5in">Facilities at UVA are state-of-the-art, with a Titan Krios equipped with a K3 camera and a Glacios equipped with a Falcon 4 camera. Charlottesville is a rather idyllic community set next to the scenic Blue Ridge
Mountains and we are two hours away from Washington, DC. Applicants should write to Ed Egelman,
<a href="mailto:egelman@virginia.edu">egelman@virginia.edu</a>, and include a CV and the names and email addresses of three references.<o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal">Recent Representative Publications<o:p></o:p></p>
<p class="MsoNormal" style="text-autospace:none">DiMaio, F., Yu, X., Rensen, E., Krupovic, M., Prangishvili, D. and Egelman, E.H. (2015). A Virus that Infects a Hyperthermophile Encapsidates A-Form DNA, Science 348, 914-7.<o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="p1" style="margin-left:0in;line-height:normal"><span style="font-size:12.0pt;font-family:"Calibri",sans-serif">Wang, F., Gu, Y., O’Brien, J.P., Yi, S.M., Yalcin, S.E., Srikanth, V., Shen, C., Vu, D., Ing, N.L., Hochbaum, A.I.<i>,</i> Egelman, E.H.
and Malvankar, N.S. (2019). Structure of Microbial Nanowires Reveals Stacked Hemes that Transport Electrons over Micrometers. Cell<i>
</i>177, 361-369</span><span style="font-size:12.0pt;font-family:"Calibri",sans-serif;color:windowtext"><o:p></o:p></span></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal">Wang, F., Cvirkaite-Krupovic, V., Kreutzberger, M.A,B., Su, Z., de Oliveira, G.A.P., Osinski, T., Sherman, N., DiMaio, F., Wall, J.S., Prangishvili, D., Krupovic, M. and Egelman, E.H. (2019). An extensively glycosylated archaeal pilus survives
extreme conditions. Nature Microbiology 4, 1401-1410.<o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal">Kreutzberger, M.A.B., Ewing, C., Poly, F., Wang, F. and Egelman, E.H. (2020). Atomic structure of the
<i>Campylobacter jejuni</i> flagellar filament reveals how <span style="font-family:"Cambria Math",serif">
𝝐</span> <i>Proteobacteria</i> escaped Toll-like receptor 5 surveillance. Proc. Natl. Acad. Sci. U.S.A.
<b>117</b>, 16985-16991.<o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal">Wang, F., Baquero, D.P., Beltran, L., Su, Z., Osinski, T., Zheng, W., Prangishvili, D., Krupovic, M. and Egelman, E.H. (2020). Structures of filamentous viruses infecting hyperthermophilic archaea explain DNA stabilization in extreme environments.
Proc. Natl. Acad. Sci. U.S.A. <b>117</b>, 19643-19652.<o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="EndNoteBibliography">Zheng, W., Pena, A., Ilangovan, A., Clark, J.N., Frankel, G., Egelman, E.H., and Costa, T.R.D. (2021). Cryoelectron-microscopy structure of the enteropathogenic Escherichia coli type III secretion system EspA filament. Proc. Natl.
Acad. Sci. U.S.A.<i> 118.<o:p></o:p></i></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<div>
<p class="MsoNormal"><span style="font-size:10.5pt;color:black"><o:p> </o:p></span></p>
</div>
<div>
<p class="MsoNormal"><span style="font-size:10.5pt;color:black"><o:p> </o:p></span></p>
</div>
<div>
<p class="MsoNormal"><span style="font-size:10.5pt;color:black">Edward Egelman<o:p></o:p></span></p>
</div>
<div>
<p class="MsoNormal"><span style="font-size:10.5pt;color:black">Harrison Distinguished Professor,<o:p></o:p></span></p>
</div>
<div>
<p class="MsoNormal"><span style="font-size:10.5pt;color:black">Department of Biochemistry and Molecular Genetics<o:p></o:p></span></p>
</div>
<div>
<p class="MsoNormal"><span style="font-size:10.5pt;color:black">Professor of Molecular Physiology and Biological Physics</span><span style="font-size:11.0pt"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.5pt;color:black">University of Virginia</span><span style="font-size:11.0pt"><o:p></o:p></span></p>
</div>
<div>
<p class="MsoNormal"><span style="font-size:10.5pt;color:black">phone: 434-924-8210<o:p></o:p></span></p>
</div>
<div>
<p class="MsoNormal"><span style="font-size:10.5pt;color:black">fax: 434-924-5069<o:p></o:p></span></p>
</div>
<div>
<p class="MsoNormal"><span style="font-size:10.5pt;color:black"><a href="mailto:egelman@virginia.edu"><span style="color:blue">egelman@virginia.edu</span></a><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.5pt;color:black"><a href="https://urldefense.proofpoint.com/v2/url?u=https-3A__egelmanlab.org_&d=DwMGaQ&c=-35OiAkTchMrZOngvJPOeA&r=L7-zyQ-04fFCMRqzLIOnx7H0exGZHwIQe_wMPuY600I&m=J-EkZp7NKxoUFw5p_rBRNK8Tdfo7uK-XU2xKkVsvE2g&s=UiOtqX2sIFKnhPiMGV8a2WWj9v-kik1elGweDiGOQr0&e="><span style="color:blue">https://egelmanlab.org/</span></a><o:p></o:p></span></p>
</div>
<p class="MsoNormal"><o:p> </o:p></p>
</div>
</body>
</html>