[3dem] Which resolution?

[Marin van Heel]

Hi Pawel,

We can indeed agree to disagree upon many basic things in life. We
apparently disagree on the basic assumptions upon which you choose to build
your science!   What I am criticising is the very foundation you use to
construct your science, namely the flawed Frank & Al-Ali (1975) formula
relating SNR and CCC! Agreed, their errors are not of your making and not
your responsibility!  It is, however, your choice and your judgement to
build upon that flawed foundation.  At the end of the day, your construct,
even when based on shaky foundations created by others, will remain your
responsibility!

Sorry,
Marin

On Sun, Feb 16, 2020 at 1:59 PM Penczek, Pawel A <
Pawel.A.Penczek at uth.tmc.edu> wrote:

> Marin,
>
> The statistics in 2010 review is fine. You may disagree with assumptions,
> but I can assure you the “statistics” (as you call it) is fine. Careful
> reading of the paper would reveal to you this much.
>
> Regards,
> Pawel
>
> On Feb 16, 2020, at 10:38 AM, Marin van Heel <marin.vanheel at googlemail.com>
> wrote:
>
> 
>
> ***** EXTERNAL EMAIL *****
> Dear Pawel and All others ....
>
> This 2010 review is - unfortunately - largely based on the flawed
> statistics I mentioned before, namely on the a priori assumption that the
> inner product of a signal vector and a noise vector are ZERO (an
> orthogonality assumption).  The (Frank & Al-Ali 1975) paper we have refuted
> on a number of occasions (for example in 2005, and most recently in our
> BioRxiv paper) but you still take that as the correct relation between SNR
> and FRC (and you never cite the criticism...).
> Sorry
> Marin
>
> On Thu, Feb 13, 2020 at 10:42 AM Penczek, Pawel A <
> Pawel.A.Penczek at uth.tmc.edu> wrote:
>
>> Dear Teige,
>>
>> I am wondering whether you are familiar with
>>
>> Resolution measures in molecular electron microscopy.
>> Penczek PA. Methods Enzymol. 2010.
>> Citation
>>
>> Methods Enzymol. 2010;482:73-100. doi: 10.1016/S0076-6879(10)82003-8.
>>
>> You will find there answers to all questions you asked and much more.
>>
>> Regards,
>> Pawel Penczek
>>
>>
>> Regards,
>> Pawel
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