[3dem] Postdoc position in cryo-EM at CNIO, Madrid

Mon Dec 28 01:00:22 PST 2020

Dear Colleagues,

There is a postdoc position available at Llorca´s group at the Structural Biology Programme, Spanish National Cancer Research Centre (CNIO) (https://urldefense.com/v3/__https://www.cnio.es/en/research-innovation/scientific-programmes/structural-biology-programme/macromolecular-complexes-in-dna-damage-response-group/__;!!Mih3wA!SNJhgf69vnY9D2Ov2Esw6TRSFtwSAqLfM6Q0fnb2t2e8h0OqELOQelnBFYwC5xVWRQ$ ).

The position is funded by “la Caixa” Foundation (https://urldefense.com/v3/__https://fundacionlacaixa.org/en/__;!!Mih3wA!SNJhgf69vnY9D2Ov2Esw6TRSFtwSAqLfM6Q0fnb2t2e8h0OqELOQelnBFYywgx0OGQ$ ) to determine the structure of membrane proteins using cryo-electron microscopy (cryo-EM). The candidates must have sufficient knowledge in cryo-EM and image processing, as well as excellent knowledge of English.

The successful candidate will join a multi-disciplinary team using biochemistry, cell and molecular biology and cryo-EM to determine the structure and molecular mechanisms of complexes of relevance in cancer and human health. CNIO and the Structural Biology Programme constitute a stimulating research environment with access to excellent facilities (https://urldefense.com/v3/__https://www.cnio.es/en/__;!!Mih3wA!SNJhgf69vnY9D2Ov2Esw6TRSFtwSAqLfM6Q0fnb2t2e8h0OqELOQelnBFYyMEuSF3A$ ).

Start date: as soon as possible
Duration: between 30-34 months
Deadline for informal enquires: January 24th 2021

For informal enquiries, please email Oscar Llorca (ollorca at cnio) with your CV and an expression of interest to join our group.

Selected recent publications by the group:

1.     Zimmermann F, Serna M, Ezquerra A, Fernandez-Leiro R, Llorca O and Luders. Assembly of the asymmetric human γ-Tubulin Ring Complex by RUVBL1-RUVBL2 AAA ATPase. Sci Adv. 2020, Dec 18th issue.
2.     López-Perrote A, Hug N, González-Corpas A et al., Llorca O. Regulation of RUVBL1-RUVBL2 AAA-ATPases by the nonsense-mediated mRNA decay factor DHX34, as evidenced by Cryo-EM. Elife. 2020 Nov 18;9:e63042.
3.     Famelis N, Rivera-Calzada A, Degliesposti G et al., Llorca O, Geibel S. Architecture of the mycobacterium Type VII secretion system. Nature 2019 576(7786):321-325.
4.     Muñoz-Hernández H, Pal M, Rodríguez CF, Fernández-Leiro R, Prodromou C, Pearl LH, Llorca O.  Structural mechanism for regulation of the AAA-ATPases RUVBL1-RUVBL2 in the R2TP co-chaperone revealed by cyo-EM. Sci Adv. 2019 May 1;5(5):eaaw1616.
5.     Martino F, Mohinder Pal, Muñoz-Hernández H et al. , Pearl LH, Llorca O. RPAP3 provides a flexible scaffold for coupling HSP90 to the human R2TP co-chaperone complex. Nat Commun. 2018 Jul 31;9(1):3063.
6.     Melero R, Hug N, López-Perrote A, Yamashita A, Cáceres JF, Llorca O. The RNA helicase DHX34 functions as a scaffold for SMG1-mediated UPF1 phosphorylation. Nat Commun. 2016 7:10585.
7.     Alcorlo M, Tortajada A, Rodríguez de Córdoba S, Llorca O. Structural basis for the stabilization of the complement alternative pathway C3 convertase by properdin. Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13504-9.
8.     Melero R, Buchwald G, Castaño R et al., Conti E, Llorca O. The cryo-EM structure of the UPF-EJC complex shows UPF1 poised toward the RNA 3' end. Nat Struct Mol Biol. 2012 Apr 22;19(5):498-505, S1-2.
9.     Alcorlo M, Martínez-Barricarte R, Fernández FJ et al,, de Cordoba SR, Llorca O. Unique structure of iC3b resolved at a resolution of 24 Å by 3D-electron microscopy. Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):13236-40.

Oscar Llorca
Structural Biology Programme Director
Spanish National Cancer Research Center, CNIO

ollorca at cnio.es
Phone +34 91 732 8000 (ext. 3000 / 3033)

Melchor Fernández Almagro, 3
28029 Madrid, España
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