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<span style="font-family:"Times New Roman",serif;mso-fareast-font-family:
"Times New Roman";color:black;mso-fareast-language:EN-GB">Dear Colleagues,</span>
<div>
<p class="MsoNormal"><span style="font-family:"Times New Roman",serif;mso-fareast-font-family:
"Times New Roman";color:black;mso-fareast-language:EN-GB"> </span></p>
<p class="MsoNormal"><span style="font-family:"Times New Roman",serif;
mso-fareast-font-family:"Times New Roman";color:black;mso-ansi-language:EN-GB;
mso-fareast-language:EN-GB" lang="EN-GB">There is a postdoc position available at Llorca´s group at the Structural
Biology Programme, Spanish National Cancer Research Centre (CNIO) (</span><span style="font-family:"Times New Roman",serif;mso-fareast-font-family:
"Times New Roman";color:black;mso-fareast-language:EN-GB"><a href="https://urldefense.com/v3/__https://www.cnio.es/en/research-innovation/scientific-programmes/structural-biology-programme/macromolecular-complexes-in-dna-damage-response-group/__;!!Mih3wA!SNJhgf69vnY9D2Ov2Esw6TRSFtwSAqLfM6Q0fnb2t2e8h0OqELOQelnBFYwC5xVWRQ$" target="_blank"><span style="color:blue;mso-ansi-language:EN-GB" lang="EN-GB">https://www.cnio.es/en/research-innovation/scientific-programmes/structural-biology-programme/macromolecular-complexes-in-dna-damage-response-group/</span></a></span><span style="font-family:"Times New Roman",serif;mso-fareast-font-family:
"Times New Roman";color:black;mso-ansi-language:EN-GB;mso-fareast-language:
EN-GB" lang="EN-GB">).</span></p>
<p class="MsoNormal"><span style="font-family:"Times New Roman",serif;
mso-fareast-font-family:"Times New Roman";color:black;mso-ansi-language:EN-GB;
mso-fareast-language:EN-GB" lang="EN-GB"> </span></p>
<p class="MsoNormal"><span style="font-family:"Times New Roman",serif;
mso-fareast-font-family:"Times New Roman";color:black;mso-ansi-language:EN-GB;
mso-fareast-language:EN-GB" lang="EN-GB">The position is funded by “la Caixa” Foundation (<a href="https://urldefense.com/v3/__https://fundacionlacaixa.org/en/__;!!Mih3wA!SNJhgf69vnY9D2Ov2Esw6TRSFtwSAqLfM6Q0fnb2t2e8h0OqELOQelnBFYywgx0OGQ$">https://fundacionlacaixa.org/en/</a>)
to determine the structure of membrane proteins using cryo-electron microscopy (cryo-EM). The candidates must have sufficient knowledge in cryo-EM and image processing, as well as excellent knowledge of English.</span><span style="font-family:"Times New Roman",serif;mso-fareast-font-family:"Times New Roman";
color:black;mso-fareast-language:EN-GB"></span></p>
<p class="MsoNormal"><span style="font-family:"Times New Roman",serif;
mso-fareast-font-family:"Times New Roman";color:black;mso-ansi-language:EN-GB;
mso-fareast-language:EN-GB" lang="EN-GB"> </span><span style="font-family:"Times New Roman",serif;
mso-fareast-font-family:"Times New Roman";color:black;mso-fareast-language:
EN-GB"></span></p>
<p class="MsoNormal"><span style="font-family:"Times New Roman",serif;
mso-fareast-font-family:"Times New Roman";color:black;mso-ansi-language:EN-GB;
mso-fareast-language:EN-GB" lang="EN-GB">The successful candidate will join a multi-disciplinary team using
biochemistry, cell and molecular biology and cryo-EM to determine the structure and molecular mechanisms of complexes of relevance in cancer and human health. CNIO and the Structural Biology Programme constitute a stimulating research environment with access
to excellent facilities (<a href="https://urldefense.com/v3/__https://www.cnio.es/en/__;!!Mih3wA!SNJhgf69vnY9D2Ov2Esw6TRSFtwSAqLfM6Q0fnb2t2e8h0OqELOQelnBFYyMEuSF3A$">https://www.cnio.es/en/</a>). </span></p>
<p class="MsoNormal"><span style="font-family:"Times New Roman",serif;
mso-fareast-font-family:"Times New Roman";color:black;mso-ansi-language:EN-GB;
mso-fareast-language:EN-GB" lang="EN-GB"> </span></p>
<p class="MsoNormal"><span style="font-family:"Times New Roman",serif;
mso-fareast-font-family:"Times New Roman";color:black;mso-ansi-language:EN-GB;
mso-fareast-language:EN-GB" lang="EN-GB">Start date: as soon as possible</span><span style="font-family:"Times New Roman",serif;mso-fareast-font-family:"Times New Roman";
color:black;mso-fareast-language:EN-GB"></span></p>
<p class="MsoNormal"><span style="font-family:"Times New Roman",serif;
mso-fareast-font-family:"Times New Roman";color:black;mso-ansi-language:EN-GB;
mso-fareast-language:EN-GB" lang="EN-GB">Duration: between 30-34 months</span><span style="font-family:"Times New Roman",serif;mso-fareast-font-family:"Times New Roman";
color:black;mso-fareast-language:EN-GB"></span></p>
<p class="MsoNormal"><span style="font-family:"Times New Roman",serif;
mso-fareast-font-family:"Times New Roman";color:black;mso-ansi-language:EN-GB;
mso-fareast-language:EN-GB" lang="EN-GB">Deadline for informal enquires: January 24<sup>th</sup> 2021</span></p>
<p class="MsoNormal"><span style="font-family:"Times New Roman",serif;
mso-fareast-font-family:"Times New Roman";color:black;mso-ansi-language:EN-GB;
mso-fareast-language:EN-GB" lang="EN-GB"> </span><span style="font-family:"Times New Roman",serif;
mso-fareast-font-family:"Times New Roman";color:black;mso-fareast-language:
EN-GB"></span></p>
<p class="MsoNormal"><span style="font-family:"Times New Roman",serif;
mso-fareast-font-family:"Times New Roman";color:black;mso-ansi-language:EN-GB;
mso-fareast-language:EN-GB" lang="EN-GB">For informal enquiries, please email Oscar Llorca (ollorca@cnio) with
your CV and an expression of interest to join our group.</span></p>
<p class="MsoNormal"><span style="font-family:"Times New Roman",serif;mso-fareast-font-family:
"Times New Roman";color:black;mso-fareast-language:EN-GB"> </span></p>
<p class="MsoNormal"><span style="font-family:"Times New Roman",serif;mso-fareast-font-family:
"Times New Roman";color:black;mso-fareast-language:EN-GB"><br>
</span></p>
<p class="MsoNormal"><span style="font-family:"Times New Roman",serif;
mso-fareast-font-family:"Times New Roman";color:black;mso-ansi-language:EN-GB;
mso-fareast-language:EN-GB" lang="EN-GB">Selected recent publications by the group:</span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Times New Roman",serif;
mso-fareast-font-family:"Times New Roman";color:black;mso-ansi-language:EN-GB;
mso-fareast-language:EN-GB" lang="EN-GB"> </span></p>
<p class="MsoNormal" style="margin-left:18.0pt;text-indent:-18.0pt;mso-list:l0 level1 lfo1">
<span style="font-size:10.0pt;font-family:"Times New Roman",serif;
mso-fareast-font-family:"Times New Roman";color:black;mso-ansi-language:EN-US;
mso-fareast-language:EN-GB" lang="EN-US"><span style="mso-list:Ignore">1.<span style="font:7.0pt "Times New Roman"">
</span></span></span><span style="font-size:10.0pt;font-family:"Times New Roman",serif;mso-fareast-font-family:
"Times New Roman";color:black;mso-ansi-language:ES;mso-fareast-language:EN-GB" lang="ES">Zimmermann F, Serna M, Ezquerra A, Fernandez-Leiro R, Llorca
O and Luders. </span><i style="mso-bidi-font-style:normal"><span style="font-size:10.0pt;
font-family:"Times New Roman",serif;mso-fareast-font-family:"Times New Roman";
color:black;mso-ansi-language:EN-US;mso-fareast-language:EN-GB" lang="EN-US">Assembly of
the asymmetric human </span></i><i style="mso-bidi-font-style:normal"><span style="font-size:10.0pt;font-family:"Times New Roman",serif;mso-fareast-font-family:
"Times New Roman";color:black;mso-ansi-language:ES;mso-fareast-language:EN-GB" lang="ES">γ</span></i><i style="mso-bidi-font-style:normal"><span style="font-size:10.0pt;
font-family:"Times New Roman",serif;mso-fareast-font-family:"Times New Roman";
color:black;mso-ansi-language:EN-US;mso-fareast-language:EN-GB" lang="EN-US">-Tubulin
Ring Complex by RUVBL1-RUVBL2 AAA ATPase. </span></i><span style="font-size:10.0pt;font-family:"Times New Roman",serif;mso-fareast-font-family:
"Times New Roman";color:black;mso-ansi-language:EN-US;mso-fareast-language:
EN-GB" lang="EN-US">Sci Adv. 2020, Dec
18<sup>th</sup> issue.</span></p>
<p class="MsoNormal" style="margin-left:18.0pt;text-indent:-18.0pt;mso-list:l0 level1 lfo1">
<span style="font-size:10.0pt;font-family:"Times New Roman",serif;
mso-fareast-font-family:"Times New Roman";color:black;mso-ansi-language:EN-US;
mso-fareast-language:EN-GB" lang="EN-US"><span style="mso-list:Ignore">2.<span style="font:7.0pt "Times New Roman"">
</span></span></span><span style="font-size:10.0pt;font-family:"Times New Roman",serif;
mso-fareast-font-family:"Times New Roman";color:black;mso-ansi-language:EN-GB;
mso-fareast-language:EN-GB" lang="EN-GB">López-Perrote A, Hug N, González-Corpas A et al.,
Llorca O. </span><i style="mso-bidi-font-style:normal"><span style="font-size:10.0pt;font-family:"Times New Roman",serif;mso-fareast-font-family:
"Times New Roman";color:black;mso-ansi-language:EN-US;mso-fareast-language:
EN-GB" lang="EN-US">Regulation of
RUVBL1-RUVBL2 AAA-ATPases by the nonsense-mediated mRNA decay factor DHX34, as evidenced by Cryo-EM</span></i><span style="font-size:10.0pt;font-family:"Times New Roman",serif;mso-fareast-font-family:
"Times New Roman";color:black;mso-ansi-language:EN-US;mso-fareast-language:
EN-GB" lang="EN-US">.
Elife. 2020 Nov 18;9:e63042. </span></p>
<p class="MsoNormal" style="margin-left:18.0pt;text-indent:-18.0pt;mso-list:l0 level1 lfo1">
<span style="font-size:10.0pt;font-family:"Times New Roman",serif;
mso-fareast-font-family:"Times New Roman";color:black;mso-ansi-language:EN-GB;
mso-fareast-language:EN-GB;mso-bidi-font-style:italic" lang="EN-GB"><span style="mso-list:
Ignore">3.<span style="font:7.0pt "Times New Roman"">
</span></span></span><span style="font-size:10.0pt;font-family:"Times New Roman",serif;
mso-fareast-font-family:"Times New Roman";color:black;mso-ansi-language:EN-US;
mso-fareast-language:EN-GB" lang="EN-US">Famelis N, Rivera-Calzada A, Degliesposti G et al.,
Llorca O, Geibel S. <i style="mso-bidi-font-style:normal">Architecture of the mycobacterium Type VII secretion system</i>.</span><span style="font-size:10.0pt;
font-family:"Times New Roman",serif;mso-fareast-font-family:"Times New Roman";
color:black;mso-ansi-language:EN-GB;mso-fareast-language:EN-GB;mso-bidi-font-style:
italic" lang="EN-US">
</span><span style="font-size:10.0pt;font-family:"Times New Roman",serif;
mso-fareast-font-family:"Times New Roman";color:black;mso-ansi-language:EN-US;
mso-fareast-language:EN-GB" lang="EN-US">Nature 2019
</span><span style="font-size:10.0pt;font-family:"Times New Roman",serif;mso-fareast-font-family:
"Times New Roman";color:black;mso-ansi-language:EN-GB;mso-fareast-language:
EN-GB" lang="EN-GB">576(7786):321-325.<span style="mso-bidi-font-style:italic"></span></span></p>
<p class="MsoNormal" style="margin-left:18.0pt;text-indent:-18.0pt;mso-list:l0 level1 lfo1">
<span style="font-size:10.0pt;font-family:"Times New Roman",serif;
mso-fareast-font-family:"Times New Roman";color:black;mso-ansi-language:EN-GB;
mso-fareast-language:EN-GB;mso-bidi-font-style:italic" lang="EN-GB"><span style="mso-list:
Ignore">4.<span style="font:7.0pt "Times New Roman"">
</span></span></span><span style="font-size:10.0pt;font-family:"Times New Roman",serif;
mso-fareast-font-family:"Times New Roman";color:black;mso-ansi-language:EN-GB;
mso-fareast-language:EN-GB" lang="EN-GB">Muñoz-Hernández H, Pal M, Rodríguez CF, Fernández-Leiro
R, Prodromou C, Pearl LH, Llorca O.<span style="mso-spacerun:yes"> </span></span><i style="mso-bidi-font-style:normal"><span style="font-size:10.0pt;font-family:"Times New Roman",serif;
mso-fareast-font-family:"Times New Roman";color:black;mso-ansi-language:EN-US;
mso-fareast-language:EN-GB" lang="EN-US">Structural
mechanism for regulation of the AAA-ATPases RUVBL1-RUVBL2 in the R2TP co-chaperone revealed by cyo-EM</span></i><span style="font-size:10.0pt;font-family:"Times New Roman",serif;
mso-fareast-font-family:"Times New Roman";color:black;mso-ansi-language:EN-US;
mso-fareast-language:EN-GB" lang="EN-US">.</span><span style="font-size:10.0pt;
font-family:"Times New Roman",serif;mso-fareast-font-family:"Times New Roman";
color:black;mso-ansi-language:EN-GB;mso-fareast-language:EN-GB;mso-bidi-font-style:
italic" lang="EN-US">
</span><span style="font-size:10.0pt;font-family:"Times New Roman",serif;
mso-fareast-font-family:"Times New Roman";color:black;mso-ansi-language:EN-US;
mso-fareast-language:EN-GB" lang="EN-US">Sci Adv. 2019 May 1;5(5):eaaw1616.
</span><span style="font-size:10.0pt;font-family:"Times New Roman",serif;
mso-fareast-font-family:"Times New Roman";color:black;mso-ansi-language:EN-GB;
mso-fareast-language:EN-GB;mso-bidi-font-style:italic" lang="EN-GB"></span></p>
<p class="MsoNormal" style="margin-left:18.0pt;text-indent:-18.0pt;mso-list:l0 level1 lfo1">
<span style="font-size:10.0pt;font-family:"Times New Roman",serif;
mso-fareast-font-family:"Times New Roman";color:black;mso-ansi-language:EN-GB;
mso-fareast-language:EN-GB;mso-bidi-font-style:italic" lang="EN-GB"><span style="mso-list:
Ignore">5.<span style="font:7.0pt "Times New Roman"">
</span></span></span><span style="font-size:10.0pt;font-family:"Times New Roman",serif;
mso-fareast-font-family:"Times New Roman";color:black;mso-ansi-language:EN-GB;
mso-fareast-language:EN-GB" lang="EN-GB">Martino F, Mohinder Pal, Muñoz-Hernández H et al.
, Pearl LH, Llorca O. </span><i style="mso-bidi-font-style:normal"><span style="font-size:10.0pt;font-family:"Times New Roman",serif;
mso-fareast-font-family:"Times New Roman";color:black;mso-ansi-language:EN-US;
mso-fareast-language:EN-GB" lang="EN-US">RPAP3
provides a flexible scaffold for coupling HSP90 to the human R2TP co-chaperone complex</span></i><span style="font-size:10.0pt;font-family:"Times New Roman",serif;mso-fareast-font-family:
"Times New Roman";color:black;mso-ansi-language:EN-US;mso-fareast-language:
EN-GB" lang="EN-US">.</span><span style="font-size:10.0pt;font-family:"Times New Roman",serif;
mso-fareast-font-family:"Times New Roman";color:black;mso-ansi-language:EN-GB;
mso-fareast-language:EN-GB;mso-bidi-font-style:italic" lang="EN-US">
</span><span style="font-size:10.0pt;font-family:"Times New Roman",serif;
mso-fareast-font-family:"Times New Roman";color:black;mso-ansi-language:EN-US;
mso-fareast-language:EN-GB" lang="EN-US">Nat Commun. 2018 Jul 31;9(1):3063.</span><span style="font-size:10.0pt;font-family:"Times New Roman",serif;
mso-fareast-font-family:"Times New Roman";color:black;mso-ansi-language:EN-GB;
mso-fareast-language:EN-GB;mso-bidi-font-style:italic" lang="EN-GB"></span></p>
<p class="MsoNormal" style="margin-left:18.0pt;text-indent:-18.0pt;mso-list:l0 level1 lfo1">
<span style="font-size:10.0pt;font-family:"Times New Roman",serif;
mso-fareast-font-family:"Times New Roman";color:black;mso-ansi-language:EN-GB;
mso-fareast-language:EN-GB" lang="EN-GB"><span style="mso-list:Ignore">6.<span style="font:7.0pt "Times New Roman"">
</span></span></span><span style="font-size:10.0pt;font-family:"Times New Roman",serif;
mso-fareast-font-family:"Times New Roman";color:black;mso-ansi-language:EN-GB;
mso-fareast-language:EN-GB" lang="EN-GB">Melero R, Hug N, López-Perrote A, Yamashita A, Cáceres
JF, Llorca O. </span><i style="mso-bidi-font-style:normal"><span style="font-size:10.0pt;font-family:"Times New Roman",serif;
mso-fareast-font-family:"Times New Roman";color:black;mso-ansi-language:EN-US;
mso-fareast-language:EN-GB" lang="EN-US">The RNA helicase
DHX34 functions as a scaffold for SMG1-mediated UPF1 phosphorylation</span></i><span style="font-size:
10.0pt;font-family:"Times New Roman",serif;mso-fareast-font-family:"Times New Roman";
color:black;mso-ansi-language:EN-US;mso-fareast-language:EN-GB" lang="EN-US">.</span><span style="font-size:10.0pt;font-family:"Times New Roman",serif;
mso-fareast-font-family:"Times New Roman";color:black;mso-ansi-language:EN-GB;
mso-fareast-language:EN-GB;mso-bidi-font-style:italic" lang="EN-US">
</span><span style="font-size:10.0pt;font-family:"Times New Roman",serif;
mso-fareast-font-family:"Times New Roman";color:black;mso-ansi-language:EN-US;
mso-fareast-language:EN-GB" lang="EN-US">Nat Commun. 2016 7:10585</span><span style="font-size:10.0pt;font-family:"Times New Roman",serif;mso-fareast-font-family:
"Times New Roman";color:black;mso-ansi-language:EN-GB;mso-fareast-language:
EN-GB;mso-bidi-font-style:italic" lang="EN-GB">.</span><span style="font-size:
10.0pt;font-family:"Times New Roman",serif;mso-fareast-font-family:"Times New Roman";
color:black;mso-ansi-language:EN-GB;mso-fareast-language:EN-GB" lang="EN-GB"></span></p>
<p class="MsoNormal" style="margin-left:18.0pt;text-indent:-18.0pt;mso-list:l0 level1 lfo1">
<span style="font-size:10.0pt;font-family:"Times New Roman",serif;
mso-fareast-font-family:"Times New Roman";color:black;mso-ansi-language:EN-GB;
mso-fareast-language:EN-GB;mso-bidi-font-style:italic" lang="EN-GB"><span style="mso-list:
Ignore">7.<span style="font:7.0pt "Times New Roman"">
</span></span></span><span style="font-size:10.0pt;font-family:"Times New Roman",serif;
mso-fareast-font-family:"Times New Roman";color:black;mso-ansi-language:EN-GB;
mso-fareast-language:EN-GB" lang="EN-GB">Alcorlo M, Tortajada A, Rodríguez de Córdoba S, Llorca
O. </span><i style="mso-bidi-font-style:normal"><span style="font-size:10.0pt;font-family:"Times New Roman",serif;mso-fareast-font-family:
"Times New Roman";color:black;mso-ansi-language:EN-US;mso-fareast-language:
EN-GB" lang="EN-US">Structural basis for
the stabilization of the complement alternative pathway C3 convertase by properdin</span></i><span style="font-size:
10.0pt;font-family:"Times New Roman",serif;mso-fareast-font-family:"Times New Roman";
color:black;mso-ansi-language:EN-US;mso-fareast-language:EN-GB" lang="EN-US">.</span><span style="font-size:10.0pt;font-family:"Times New Roman",serif;
mso-fareast-font-family:"Times New Roman";color:black;mso-ansi-language:EN-GB;
mso-fareast-language:EN-GB;mso-bidi-font-style:italic" lang="EN-US">
</span><span style="font-size:10.0pt;font-family:"Times New Roman",serif;
mso-fareast-font-family:"Times New Roman";color:black;mso-ansi-language:EN-US;
mso-fareast-language:EN-GB" lang="EN-US">Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13504-9.</span><span style="font-size:10.0pt;font-family:
"Times New Roman",serif;mso-fareast-font-family:"Times New Roman";color:black;
mso-ansi-language:EN-GB;mso-fareast-language:EN-GB;mso-bidi-font-style:italic" lang="EN-GB"></span></p>
<p class="MsoNormal" style="margin-left:18.0pt;text-indent:-18.0pt;mso-list:l0 level1 lfo1">
<span style="font-size:10.0pt;font-family:"Times New Roman",serif;
mso-fareast-font-family:"Times New Roman";color:black;mso-ansi-language:EN-GB;
mso-fareast-language:EN-GB;mso-bidi-font-style:italic" lang="EN-GB"><span style="mso-list:
Ignore">8.<span style="font:7.0pt "Times New Roman"">
</span></span></span><span style="font-size:10.0pt;font-family:"Times New Roman",serif;
mso-fareast-font-family:"Times New Roman";color:black;mso-ansi-language:EN-GB;
mso-fareast-language:EN-GB" lang="EN-GB">Melero R, Buchwald G, Castaño R et al., Conti E,
Llorca O. </span><i style="mso-bidi-font-style:normal"><span style="font-size:10.0pt;font-family:"Times New Roman",serif;mso-fareast-font-family:
"Times New Roman";color:black;mso-ansi-language:EN-US;mso-fareast-language:
EN-GB" lang="EN-US">The cryo-EM structure
of the UPF-EJC complex shows UPF1 poised toward the RNA 3' end</span></i><span style="font-size:10.0pt;font-family:
"Times New Roman",serif;mso-fareast-font-family:"Times New Roman";color:black;
mso-ansi-language:EN-US;mso-fareast-language:EN-GB" lang="EN-US">.
Nat Struct Mol Biol. 2012 Apr 22;19(5):498-505, S1-2.</span><span style="font-size:10.0pt;
font-family:"Times New Roman",serif;mso-fareast-font-family:"Times New Roman";
color:black;mso-ansi-language:EN-GB;mso-fareast-language:EN-GB;mso-bidi-font-style:
italic" lang="EN-GB"></span></p>
<p class="MsoNormal" style="margin-left:18.0pt;text-indent:-18.0pt;mso-list:l0 level1 lfo1">
<span style="font-size:10.0pt;font-family:"Times New Roman",serif;
mso-fareast-font-family:"Times New Roman";color:black;mso-ansi-language:EN-GB;
mso-fareast-language:EN-GB;mso-bidi-font-style:italic" lang="EN-GB"><span style="mso-list:
Ignore">9.<span style="font:7.0pt "Times New Roman"">
</span></span></span><span style="font-size:10.0pt;font-family:"Times New Roman",serif;
mso-fareast-font-family:"Times New Roman";color:black;mso-ansi-language:EN-GB;
mso-fareast-language:EN-GB;mso-bidi-font-style:italic" lang="EN-GB">Alcorlo M, Martínez-Barricarte
R, Fernández FJ et al,, de Cordoba SR, Llorca O. </span><i><span style="font-size:10.0pt;font-family:"Times New Roman",serif;
mso-fareast-font-family:"Times New Roman";color:black;mso-ansi-language:EN-US;
mso-fareast-language:EN-GB" lang="EN-US">Unique structure
of iC3b resolved at a resolution of 24 Å by 3D-electron microscopy</span></i><span style="font-size:
10.0pt;font-family:"Times New Roman",serif;mso-fareast-font-family:"Times New Roman";
color:black;mso-ansi-language:EN-US;mso-fareast-language:EN-GB;mso-bidi-font-style:
italic" lang="EN-US">.</span><span style="font-size:10.0pt;font-family:"Times New Roman",serif;
mso-fareast-font-family:"Times New Roman";color:black;mso-ansi-language:EN-GB;
mso-fareast-language:EN-GB;mso-bidi-font-style:italic" lang="EN-US">
</span><span style="font-size:10.0pt;font-family:"Times New Roman",serif;
mso-fareast-font-family:"Times New Roman";color:black;mso-ansi-language:EN-US;
mso-fareast-language:EN-GB;mso-bidi-font-style:italic" lang="EN-US">Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):13236-40.</span><span style="font-size:10.0pt;
font-family:"Times New Roman",serif;mso-fareast-font-family:"Times New Roman";
color:black;mso-ansi-language:EN-GB;mso-fareast-language:EN-GB;mso-bidi-font-style:
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