[3dem] Cryo-EM Sample Preparation Tools

Michael Godfrin mgodfrin at nanosoftmaterials.com
Fri Nov 1 04:59:58 PDT 2019


Hello Everybody,

We wanted to inform the community that NanoSoft is now offering 2 new tools
to improve efficiency and ease of use in the cryo-EM sample preparation
workflow.

"The Igloo <https://www.nanosoftmaterials.com/igloo-system>" fits on top of
the styrofoam vitrification dewar that comes with the FEI/Thermo Fisher
Vitrobot.  It creates a more enclosed environment above the dewar, such
that this area, through which the vitrified sample is transferred to the
grid button, is less exposed to the humidity of the ambient environment.
Furthermore, it keeps the styrofoam ring from collecting ice, which is
deposited into the liquid nitrogen and can contaminate grids.  Our first
customers have been using the Igloo and have seen significant drops in ice
contamination. Furthermore, the Igloo offers features that make sample
transfer much more ergonomic, reducing accidental grid damage.

The "Autogrid Inspection Tool
<https://www.nanosoftmaterials.com/autogrid-inspection-tool>" integrates
seamlessly into the FEI/Thermo Fisher Cassette Loading Station.  Although
the Grid Clipping Station has a "groove" to check that grids are clipped
well, the Cassette Loading Station does not.  The "Autogrid Inspection
Tool" provides a convenient, low-cost, "last-chance" way to check the
quality of the clipping prior to loading autogrids into the cassette.

Please don't hesitate to reach out with any questions or comments you may
have about these new tools.


Mike


*Michael Godfrin, PhD*
*President*

*NanoSoft*
1372 Main St.
Coventry, RI 02816
Cell: (401) 829-5527
www.nanosoftmaterials.com

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