[3dem] Postdoctoral position on structure of amyloid fibrils (cryo-EM/X-ray)

[Matthias Schmidt]

Postdoctoral Position at the Institute of Protein Biochemistry, Ulm 
University (Germany),
Group Prof. Dr. M. Fändrich

The Institute of Protein Biochemistry 
(_https://www.uni-ulm.de/nawi/nawi-pbc.html_) investigates the molecular 
basis of amyloid diseases, such as Alzheimer's disease and systemic 
amyloidosis. We use a broad range of techniques from protein 
biochemistry, structural biology (in particular cryo-EM) to cell 
biology. Our strong ties to several medical institutions enable us to 
uniquely link structural biology with patient and animal samples. We 
seek for new postdoctoral co-workers with a strong background in cryo-EM 
or X-ray crystallography to strengthen our cryo-EM projects on amyloid 
fibril structures. Projects may involve protein purification and sample 
preparation, cryo-EM imaging, single particle reconstruction, structural 
modelling and the combination of structural and biological/medical data.

Recent references:
Cryo-EM fibril structures from systemic AA amyloidosis reveal the 
species complementarity of pathological amyloids.
Liberta F, Loerch S, Rennegarbe M, Schierhorn A, Westermark P, 
Westermark GT, Hazenberg BPC, Grigorieff N, Fändrich M, Schmidt M.
Nature Comm. 10, 1104 (2019)

Cryo-EM structure of a light chain-derived amyloid fibril from a patient 
with systemic AL amyloidosis.
Radamaker, L, Lin Y-H, Annamalai K, Huhn S, Hegenbart U, Schönland SO, 
Fritz G, Schmidt M, Fändrich M.
Nature Comm. 10, 1103 (2019)

If you are interested, please contact us under 
bewerbung-pbc(at)uni-ulm.de. Incoming mails will be viewed from 15 April 
2019 onwards. Position will be filled as soon as possible.


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