[3dem] PhD student position on structure of amyloid fibrils (cryo-EM)

[Matthias Schmidt]

**PhD student position at the Institute of Protein Biochemistry, Ulm 
University (Germany),
Group Prof. Dr. M. Fändrich

The Institute of Protein Biochemistry 
(_https://www.uni-ulm.de/nawi/nawi-pbc.html_) investigates the molecular 
basis of amyloid diseases, such as Alzheimer's disease and systemic 
amyloidosis. We use a broad range of techniques from protein 
biochemistry, structural biology (in particular cryo-EM) to cell 
biology. Our strong ties to several medical institutions enable us to 
uniquely link structural biology with patient and animal samples. We 
seek for new doctorate students with a very good Master degree in, for 
example, Biochemistry, Chemistry or Physics to strengthen our cryo-EM 
analysis of amyloid fibril structures. Projects may involve protein 
purification and sample preparation, cryo-EM imaging, single particle 
reconstruction, structural modelling and the combination of structural 
and biological/medical data.

Recent references:
Cryo-EM fibril structures from systemic AA amyloidosis reveal the 
species complementarity of pathological amyloids. Liberta F, Loerch S, 
Rennegarbe M, Schierhorn A, Westermark P, Westermark GT, Hazenberg BPC, 
Grigorieff N, Fändrich M, Schmidt M. Nature Comm. 10, 1104 (2019)

Cryo-EM structure of a light chain-derived amyloid fibril from a patient 
with systemic AL amyloidosis. Radamaker, L, Lin Y-H, Annamalai K, Huhn 
S, Hegenbart U, Schönland SO, Fritz G, Schmidt M, Fändrich M. Nature 
Comm. 10, 1103 (2019)

If you are interested, please contact us under 
bewerbung-pbc(at)uni-ulm.de.Incoming mails will be viewed from 15 April 
2019 onwards. Position will be filled as soon as possible.

-------------- next part --------------
An HTML attachment was scrubbed...
URL: <http://mail.ncmir.ucsd.edu/pipermail/3dem/attachments/20190322/ef34d2f4/attachment-0001.html>