[3dem] Job Opportunity for Cryo-EM Specialist at Genentech Inc., California, USA

[Claudio Ciferri]

Dear All,
the *Department of Structural Biology* *at Genentech* is expanding its
cryo-EM effort to support research and drug discovery and has an exciting
opportunity for a very motivated individual to join our cryo-EM team
as a *System
Specialist II* or *Senior System Specialist*.

*You can apply to this position using this link
<https://www.gene.com/careers/detail/201906-117146/System-Specialist-II-Senior-System-Specialist-CryoEM>.*

The successful candidate will be a technical expert in at least one of the
following areas:

*Sample preparation and optimization for cryo-EM:* the candidate should
have a strong background and proven track record in protein biochemistry,
cryo-EM grid preparation and sample optimization for cryo-EM structure
determination. Hands-on experience with different protein classes (i.e.
soluble, membrane and/or secreted) is highly desirable. Experience with one
of the automatic vitrification systems (Chameleon, Vitrojet, Cryo-writer,
etc.) would be considered a plus. Excellent communication, interpersonal
and organizational skills are essential.

*Data collection and cryo-EM operations: *the candidate should have
in-depth technical knowledge of electron microscopes, and proven
proficiency in cryo-EM grid preparation and manual and automated data
collection on 200keV and 300keV systems using SerialEM or EPU. Experience
with on-the-fly single-particle data processing, the collection and/or
processing of microED data will be considered a plus. The successful
candidate will have excellent communication, interpersonal and
organizational skills, as well as a proven track record of support and
coordination of multiple projects and users in a cryo-EM facility set-up.

*The successful candidate will be part of a diverse and stimulating
research environment focused on enabling research and drug discovery to
help patients in need. While embedded within the Genentech pipeline, the
selected candidate would also have the opportunity to initiate independent
or collaborative research efforts.  *

The cryo-EM  facility at Genentech houses a Titan Krios equipped with
post-GIF K2, a Talos 200C equipped with CetaD, a Glacios equipped with K2
(to be delivered August 2019) and another Titan Krios equipped with energy
filter and K3 (to be delivered January 2020), as well as the usual
ancillary equipment for sample preparation and plunge-freezing.

*Required qualifications: *Ph.D. or equivalent in biochemistry, biophysics,
protein engineering, and/or structural biology, with hands-on experience in
cryo-EM sample preparation and optimization and/or data collection and
equipment maintenance is required. Productive postdoctoral training and/or
industry experience highly desirable.

*Additional desired qualifications:*
- Hands-on experience optimizing the production of challenging protein
targets for structural studies
- Proficiency in cryo-EM structure determination or modeling using one or
more software packages
- Experience with MicroED data collection and data processing
- Experience with protein engineering and/or design approaches
- Analysis, design, and/or computational approaches to investigate
ligand-protein complexes
Please feel free to contact me, would you require any additional
information.
Looking forward to receiving your application.

Best
Claudio Ciferri


-- 
*Claudio Ciferri*
Sr Scientist - Structural Biology
Genentech, Inc.
1 DNA Way, MS: 247
South San Francisco, CA 94080

office: (650) 4674946
cell: (510) 5013763
ciferri.claudio at gene.com
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