[3dem] Postdoctoral Position in Cryo-EM at ICR London

[Sebastian Guettler]

Dear Colleagues,

An exciting, fully funded cryo-EM-centred postdoc project is available in my team; please see below for details. The position coincides with important upgrades to our cryo-EM infrastructure at the Institute. Closing date for applications is the 25th of August. Informal enquiries are welcome, so please get in touch if you are interested.

Thank you and best wishes,
Sebastian

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Sebastian Guettler, PhD
Team Leader
Wellcome Trust Investigator | Cancer Research UK Fellow | Lister Institute Fellow
The Institute of Cancer Research (ICR)
Divisions of Structural Biology and Cancer Biology
237 Fulham Road
London, SW3 6JB
United Kingdom

e-mail: sebastian.guettler at icr.ac.uk
web: icr.ac.uk | sguettlerlab.org
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Postdoctoral Training Fellow: Cryo-Electron Microscopy and Biophysics/Biochemistry

The Institute of Cancer Research (ICR)
Location: London (Chelsea)
Divisions: Structural Biology and Cancer Biology
Team: Structural Biology of Cell Signalling (Dr Sebastian Guettler)
Length of Contract: 3 years in the first instance
Closing date for applications: 25 August 2019

Following a Cancer Research UK Programme Foundation Award to Dr Sebastian Guettler, a Postdoctoral Training Fellow position is available in the Structural Biology of Cell Signalling team in the Divisions of Structural Biology and Cancer Biology. Work in the Guettler laboratory centres on the elucidation of signal transduction mechanisms relevant to the function of cancer cells, in particular the Wnt/beta-catenin network and telomere homeostasis and their control by poly(ADP-ribosyl)ation. Research by the team combines structural biology, both by X-ray crystallography and cryo-electron microscopy, biochemistry, biophysics and functional studies in mammalian cells. For a research overview, please visit sguettlerlab.org or icr.ac.uk.

The Cancer Research UK-funded Postdoctoral Training Fellow will analyse the function of poly(ADP-ribose)polymerase (PARP) enzymes by using a combination of cryo-electron microscopy, biophysical and biochemical approaches. The emphasis will be on the structural characterisation of proteins/protein complexes by cryo-EM and the exploration of hypotheses raised by structural findings using purified proteins in biochemical assays. The position will coincide with a major expansion of cryo-EM capabilities at the ICR in 2019/20, which will provide a state-of-the-art infrastructure and outstanding research and training opportunities.

Research in the Division of Structural Biology is aimed at understanding the structural basis for the function and regulation of proteins and protein complexes implicated in cancer. Our research programmes are complemented by close collaborations with other groups at the Institute, for example in the Divisions of Cancer Biology and Cancer Therapeutics. The Division of Structural Biology has managed facilities for protein production, with expertise in multi-subunit expression (insect cell, yeast and bacterial expression, including a 60-litre fermentor), protein crystallography and cryo-EM (FEI Tecnai T12 and F20). The installation of a state-of-the-art FEI Glacios/Falcon 3 cryo-electron microscope is currently in progress. Regular access to shared cryo-EM facilities, such as eBIC, is available. Moreover, the ICR is part of the London Consortium for Cryo-EM, hosting an FEI Titan Krios equipped with a Volta phase plate, a Gatan Bioquantum energy filter and K3 detector (available in 2019). The Division is also well-equipped with instrumentation for biophysical analysis (e.g., ITC, fluorescence, multi-angle light scattering).

For further details and to apply, please visit the ICR Careers portal:
https://icr.tal.net/vx/lang-en-GB/mobile-0/appcentre-1/brand-4/candidate/so/pm/1/pl/1/opp/796-Postdoctoral-Training-Fellow-Cryo-Electron-Microscopy-and-Biophysics-Biochemistry/en-GB

Informal enquiries can be made to sebastian.guettler at icr.ac.uk<mailto:sebastian.guettler at icr.ac.uk>. (However, please note that formal applications must be submitted online.)



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... and we have a second (in this case Wellcome Trust-funded) postdoc project available as well. Whilst not an EM project, it is closely linked to structural work in the team:

Postdoctoral Training Fellow: Cell Biology and Biochemistry of Telomere Function
(https://icr.tal.net/vx/lang-en-GB/mobile-0/appcentre-1/brand-4/candidate/so/pm/1/pl/1/opp/794-Postdoctoral-Training-Fellow-Cell-Biology-and-Biochemistry-of-Telomere-Function/en-GB).





The Institute of Cancer Research: Royal Cancer Hospital, a charitable Company Limited by Guarantee, Registered in England under Company No. 534147 with its Registered Office at 123 Old Brompton Road, London SW7 3RP.

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