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<p class="MsoNormal"><span style="font-family:Helvetica;color:black">Dear Colleagues,</span><span style="color:black"><o:p></o:p></span></p>
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<span style="font-family:Helvetica;color:black"> </span><span style="color:black"><o:p></o:p></span></p>
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<span style="font-family:Helvetica;color:black">An exciting, fully funded cryo-EM-centred postdoc project is available in my team; please see below for details. The position coincides with important upgrades to our cryo-EM infrastructure at the Institute. Closing
date for applications is the <b>25<sup>th</sup> of August</b>. Informal enquiries are welcome, so please get in touch if you are interested.<o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-family:Helvetica;color:black">Thank you and best wishes,<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-family:Helvetica;color:black">Sebastian</span><span style="color:black"><o:p></o:p></span></p>
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<span style="font-family:Helvetica;color:black"> </span><span style="color:black"><o:p></o:p></span></p>
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<span style="font-family:Helvetica;color:black">-----------------------------------------------------------<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-family:Helvetica;color:black">Sebastian Guettler, PhD<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-family:Helvetica;color:black">Team Leader<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-family:Helvetica;color:black">Wellcome Trust Investigator | Cancer Research UK Fellow | Lister Institute Fellow<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-family:Helvetica;color:black">The Institute of Cancer Research (ICR)<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-family:Helvetica;color:black">Divisions of Structural Biology and Cancer Biology<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-family:Helvetica;color:black">237 Fulham Road<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-family:Helvetica;color:black">London, SW3 6JB<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-family:Helvetica;color:black">United Kingdom<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-family:Helvetica;color:black"><o:p> </o:p></span></p>
<p class="MsoNormal"><i><span style="font-family:Helvetica;color:black">e-mail:</span></i><span style="font-family:Helvetica;color:black"> sebastian.guettler@icr.ac.uk<o:p></o:p></span></p>
<p class="MsoNormal"><i><span style="font-family:Helvetica;color:black">web:</span></i><span style="font-family:Helvetica;color:black"> icr.ac.uk | sguettlerlab.org<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-family:Helvetica;color:black">-----------------------------------------------------------<o:p></o:p></span></p>
<p class="MsoNormal"><span style="color:black"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="color:black"><o:p> </o:p></span></p>
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<b><span style="font-family:Helvetica;color:black">Postdoctoral Training Fellow: Cryo-Electron Microscopy and Biophysics/Biochemistry</span></b><span style="font-family:Helvetica;color:black"><o:p></o:p></span></p>
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<span style="font-family:Helvetica;color:black"> <o:p></o:p></span></p>
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<span style="font-family:Helvetica;color:black">The Institute of Cancer Research (ICR)<o:p></o:p></span></p>
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<i><span style="font-family:Helvetica;color:black">Location:</span></i><span class="apple-converted-space"><span style="font-family:Helvetica;color:black"> </span></span><span style="font-family:Helvetica;color:black">London (Chelsea)<o:p></o:p></span></p>
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<i><span style="font-family:Helvetica;color:black">Divisions:</span></i><span class="apple-converted-space"><span style="font-family:Helvetica;color:black"> </span></span><span style="font-family:Helvetica;color:black">Structural Biology and Cancer Biology<o:p></o:p></span></p>
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<i><span style="font-family:Helvetica;color:black">Team:</span></i><span class="apple-converted-space"><span style="font-family:Helvetica;color:black"> </span></span><span style="font-family:Helvetica;color:black">Structural Biology of Cell Signalling (Dr Sebastian
Guettler)<o:p></o:p></span></p>
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<i><span style="font-family:Helvetica;color:black">Length of Contract:</span></i><span class="apple-converted-space"><span style="font-family:Helvetica;color:black"> </span></span><span style="font-family:Helvetica;color:black">3 years in the first instance<o:p></o:p></span></p>
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<i><span style="font-family:Helvetica;color:black">Closing date for applications:<span class="apple-converted-space"> </span></span></i><span style="font-family:Helvetica;color:black">25 August 2019<o:p></o:p></span></p>
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<span style="font-family:Helvetica;color:black"> <o:p></o:p></span></p>
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<span style="font-family:Helvetica;color:black">Following a Cancer Research UK Programme Foundation Award to Dr Sebastian Guettler, a Postdoctoral Training Fellow position is available in the Structural Biology of Cell Signalling team in the Divisions of Structural
Biology and Cancer Biology. Work in the Guettler laboratory centres on the elucidation of signal transduction mechanisms relevant to the function of cancer cells, in particular the Wnt/beta-catenin network and telomere homeostasis and their control by poly(ADP-ribosyl)ation.
Research by the team combines structural biology, both by X-ray crystallography and cryo-electron microscopy, biochemistry, biophysics and functional studies in mammalian cells. For a research overview, please visit<span class="apple-converted-space"> </span><b>sguettlerlab.org</b><span class="apple-converted-space"> </span>or<span class="apple-converted-space"> </span><b>icr.ac.uk</b>.<o:p></o:p></span></p>
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<span style="font-family:Helvetica;color:black"> <o:p></o:p></span></p>
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<span style="font-family:Helvetica;color:black">The Cancer Research UK-funded Postdoctoral Training Fellow will analyse the function of poly(ADP-ribose)polymerase (PARP) enzymes by using a combination of cryo-electron microscopy, biophysical and biochemical
approaches. The emphasis will be on the structural characterisation of proteins/protein complexes by cryo-EM and the exploration of hypotheses raised by structural findings using purified proteins in biochemical assays. The position will coincide with a major
expansion of cryo-EM capabilities at the ICR in 2019/20, which will provide a state-of-the-art infrastructure and outstanding research and training opportunities.<o:p></o:p></span></p>
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<span style="font-family:Helvetica;color:black"> <o:p></o:p></span></p>
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<span style="font-family:Helvetica;color:black">Research in the Division of Structural Biology is aimed at understanding the structural basis for the function and regulation of proteins and protein complexes implicated in cancer. Our research programmes are
complemented by close collaborations with other groups at the Institute, for example in the Divisions of Cancer Biology and Cancer Therapeutics. The Division of Structural Biology has managed facilities for protein production, with expertise in multi-subunit
expression (insect cell, yeast and bacterial expression, including a 60-litre fermentor), protein crystallography and cryo-EM (FEI Tecnai T12 and F20). The installation of a state-of-the-art FEI Glacios/Falcon 3 cryo-electron microscope is currently in progress.
Regular access to shared cryo-EM facilities, such as eBIC, is available. Moreover, the ICR is part of the London Consortium for Cryo-EM, hosting an FEI Titan Krios equipped with a Volta phase plate, a Gatan Bioquantum energy filter and K3 detector (available
in 2019). The Division is also well-equipped with instrumentation for biophysical analysis (e.g., ITC, fluorescence, multi-angle light scattering).<o:p></o:p></span></p>
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<b><span style="font-family:Helvetica;color:black">For further details and to apply, please visit the ICR Careers portal:</span></b><span style="font-family:Helvetica;color:black"><o:p></o:p></span></p>
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<span style="font-family:Helvetica;color:black"><a href="https://icr.tal.net/vx/lang-en-GB/mobile-0/appcentre-1/brand-4/candidate/so/pm/1/pl/1/opp/796-Postdoctoral-Training-Fellow-Cryo-Electron-Microscopy-and-Biophysics-Biochemistry/en-GB"><span style="color:#954F72">https://icr.tal.net/vx/lang-en-GB/mobile-0/appcentre-1/brand-4/candidate/so/pm/1/pl/1/opp/796-Postdoctoral-Training-Fellow-Cryo-Electron-Microscopy-and-Biophysics-Biochemistry/en-GB</span></a><o:p></o:p></span></p>
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<span style="font-family:Helvetica;color:black"> <o:p></o:p></span></p>
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<span style="font-family:Helvetica;color:black">Informal enquiries can be made to<span class="apple-converted-space"> </span><a href="mailto:sebastian.guettler@icr.ac.uk"><span style="color:#954F72">sebastian.guettler@icr.ac.uk</span></a>. (However, please
note that formal applications must be submitted online.)<o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-family:Helvetica;color:black">--------------<o:p></o:p></span></p>
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<span style="font-family:Helvetica;color:black">... and we have a second (in this case Wellcome Trust-funded) postdoc project available as well. Whilst not an EM project, it is closely linked to structural work in the team:<o:p></o:p></span></p>
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<b><span style="font-family:Helvetica;color:black">Postdoctoral Training Fellow: Cell Biology and Biochemistry of Telomere Function</span></b><span style="font-family:Helvetica;color:black"><o:p></o:p></span></p>
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<span style="font-family:Helvetica;color:black">(<a href="https://icr.tal.net/vx/lang-en-GB/mobile-0/appcentre-1/brand-4/candidate/so/pm/1/pl/1/opp/794-Postdoctoral-Training-Fellow-Cell-Biology-and-Biochemistry-of-Telomere-Function/en-GB"><span style="color:#954F72">https://icr.tal.net/vx/lang-en-GB/mobile-0/appcentre-1/brand-4/candidate/so/pm/1/pl/1/opp/794-Postdoctoral-Training-Fellow-Cell-Biology-and-Biochemistry-of-Telomere-Function/en-GB</span></a>).<o:p></o:p></span></p>
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