[3dem] THE EIGHTH BRAZIL SCHOOL FOR SINGLE PARTICLE CRYO-EM (27 Sept - 9 Oct 2018)

[Marin van Heel]

Third Announcement

THE EIGHTH BRAZIL SCHOOL FOR SINGLE PARTICLE CRYO-EM.

27 Sept - 9 Oct 2018, Mairiporã, SP Brazil (www.brazil-school.org 
<http://www.brazil-school.org>)

Our single-particle school is a unique and intensive 12-day hands-on 
course/workshop, in which theory and practice are tightly intertwined. 
The understanding of the principles of cryo-EM data processing stands 
central in this event and a few cryo-EM pioneers will explain the 
approaches to the participants to a level where they can apply it 
themselves. The spectrum of topics covered suits attendees who are new 
to the field as well as those for whom the technique is of growing 
importance and who wish to acquire an in-depth understanding of the 
fundamental principles.  The final days of the meeting will be devoted 
to advanced topics such as high-resolution refinements and the 
processing of heterogeneous data sets ("4D cryo–EM”). Advanced topics 
will include:

1) Optimizing data collection with direct electrons detectors and 
exploiting movies.
2) Full data set automatic CTF correction.
3) Correction of anisotropic magnification.
4) MSA data compression + unsupervised classification, from the very 
inventors of 2D- and 3D-classification.
5) Reaching atomic resolution without bias: alignment-by-classification 
(ABC-4D).
6) Unbiased "Random Startup" of 3D and 4D reconstructions.
7) Projection Matching and Angular Reconstitution: Pros &Cons.
8) 4D refinement procedures for high-resolution results using different 
software systems: Frealign/cisTEM, cryoSPARC, Relion, IMAGIC, etc.
9) Fitting and refining atomic coordinates in high-resolution cryo-EM 
maps using programs such as REFMAC and Coot.
10) Validation and interpretation of final results using reproducible 
(local) resolution metrics.

Kind regards,

Marin van Heel

Note: Registrations will remain open until June 10th, because of the 
forthcoming long holiday weekend. The results of the final selection 
will be announced by Monday the 18th of June.

==============================================================

     Prof Dr Ir Marin van Heel

     Laboratório Nacional de Nanotecnologia - LNNano
     CNPEM/LNNano, Campinas, Brazil

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