[3dem] Opportunities at Schrödinger: Cryo-EM Refinement Specialist

Frank Pagliaro frank.pagliaro at schrodinger.com
Thu May 4 12:38:19 PDT 2017


Schrödinger, a computational chemistry company funded in part by Bill
Gates, has over 300 engineers, computational chemists, medicinal chemists,
structural biologists, biochemists, biologists and support staff, all
dedicated to revolutionizing drug discovery through the development and use
of breakthrough computational methods.  Through significant long-term
investments in basic research, we have made scientific advancements across
many areas of drug discovery and have contributed hundreds of peer-reviewed
scientific publications, which are frequently among the most heavily cited
in their fields.  These advancements have been instrumental in the success
of our structure-based drug discovery efforts, with three of our programs
already in clinical trials and a fourth expected later this year. (
https://www.schrodinger.com/publications, https://www.schrodinger.com/news)

We are now seeking a cryo-electron microscopy refinement specialist to join
this interdisciplinary team. This specialist, based in our New York office,
will help us to combine our expertise in structure-based drug discovery
with current breakthroughs in structural biology to further accelerate the
drug discovery process.

*Responsibilities:*

-Refine and evaluate high resolution single particle cryo-EM data sets

-Actively participate in internal and collaborative structure-based drug
discovery projects

-Work with the internal software development team to improve Schrödinger’s
structure-based drug discovery technologies

*Requirements:*

-Ph.D. in structural biology, chemistry, biophysics, or a related field

-Hands-on experience working with single particle cryo-EM data collection
for biological specimens

-Experience working with single particle cryo-EM refinement packages (EMAN,
FreeAign, Relion, CryoSPARC, etc.), to refine high resolution data sets
from biological specimens

-Strong communication skills

*Preferred Skills:*

-Experience with methods to account for global and local structural
heterogeneity in single particle cryo-EM data

-Knowledge of molecular modeling theory and applications

-Experience with pharmaceutical or biotechnology problems

-Python programming experience


Benefits include medical, dental, 401(k), flexible spending account,
vacation, tuition reimbursement, and a flexible work schedule.

*Schrödinger is an equal opportunity employer.*

If you are interested, please apply through our website:
https://www.schrodinger.com/careers/other-positions/cryo-em-refinement-specialist

-- 
Frank Pagliaro
Schrödinger, Inc.
120 W 45th St
New York, NY 10036
(774) 212-2478
frank.pagliaro at schrodinger.com
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