[3dem] Postdoc job at Birkbeck College, London

[Carolyn Moores]

Dear colleagues

*Institute of Structural and Molecular Biology, Birkbeck College, London***

*Department of Biological Sciences*

**

*Post Doctoral Researcher - Structural Biology(Ref: 11832)*

*Full time, fixed term appointment for up to 3 years *

We are seeking a motivated and creative Post Doctoral Researcher (Level 
2) to elucidate inhibition mechanisms of mitotic kinesin motors using 
cryo-electron microscopy. This work is funded by Worldwide Cancer 
Research and will be performed as part of the research team led by Prof 
Carolyn Moores.

Inhibitors of mitotic kinesins block mitosis and are potential cancer 
therapies. Gain-of-function inhibitors specifically block kinesin 
function by inducing a tight microtubule binding state. However, the 
structures of these microtubule-bound inhibitor-blocked motors, and 
therefore the precise inhibition mechanism(s) of these potentially 
important molecules, are not known. The goal of this project is to 
determine these mechanisms of mitotic kinesin inhibition using 
state-of-the-art cryo-electron microscopy structure determination and 
molecular modeling. The appointee will be a member of a team working on 
regulatory mechanisms of cytoskeleton dynamics 
(http://people.cryst.bbk.ac.uk/~ubcg62d/ 
<http://people.cryst.bbk.ac.uk/%7Eubcg62d/>)and will interact with 
members of the Birkbeck Electron Microscopy group.

The Birkbeck EM lab is located in an outstanding, collaborative 
environment for structural, molecular and cellular biology, in the 
Crystallography section of the Department of Biological Sciences, which 
forms part of the joint Institute for Structural and Molecular Biology 
with University College London. The EM lab is equipped with a 300 kV 
Polara microscope and a 200 kV FEG system with K2 and DE20 direct 
electron detectors, and 120 kV and 100 kV cryo microscopes, as well as 
sample preparation equipment for single particles, high pressure 
freezing, vitrified sections and freeze substitution.

Applicants should have a PhD in structural biology, biochemistry or a 
related area, and have relevant research publications.

**

*Salary:*Grade 7 of the College's London Pay Scale, which is £36,150 to 
£41,318 per annum, depending on experience.

This is a full-time and fixed term position for up to three years. The 
appointment may be subject to a probationary period of twelve months. 
Birkbeck also provides a generous final salary pension scheme, 31 days 
paid leave, flexible working arrangements and other great benefits.

For details and application forms, please see:http://tinyurl.com/z7vc66t

**

*The closing date for completed applications is midnight on April 7^th , 
2016*

*Interviews will be held early May*

Informal enquiries can be made to Carolyn Moores 
(c.moores at mail.cryst.bbk.ac.uk)

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