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Dear colleagues<br>
<br>
<p class="MsoNormal" style="mso-outline-level:5"><b><span
style="font-size:11.0pt;font-family:Arial;mso-fareast-font-family:"Times
New Roman";
mso-ansi-language:EN-US" lang="EN-US">Institute of Structural
and Molecular Biology,
Birkbeck College, London</span></b><b><span
style="font-size:11.0pt;font-family:
Arial;mso-fareast-font-family:"Times New Roman""><o:p></o:p></span></b></p>
<p class="MsoNormal" style="mso-outline-level:5"><b
style="mso-bidi-font-weight:
normal"><span
style="font-size:11.0pt;font-family:Arial;mso-fareast-font-family:
"Times New Roman"">Department of Biological Sciences<span
style="mso-bidi-font-weight:
bold"><o:p></o:p></span></span></b></p>
<p class="MsoNormal"><b style="mso-bidi-font-weight:normal"><span
style="font-size:11.0pt;font-family:Arial;layout-grid-mode:line"> </span></b><span
style="font-size:11.0pt;font-family:Arial"><o:p></o:p></span></p>
<p class="MsoNormal" style="mso-hyphenate:none;tab-stops:center
225.65pt"><b style="mso-bidi-font-weight:normal"><span
style="font-size:11.0pt;font-family:
Arial">Post Doctoral Researcher - Structural Biology<span
style="mso-bidi-font-weight:
bold"> </span>(Ref: 11832)</span></b><span
style="font-size:11.0pt;font-family:
Arial"><o:p></o:p></span></p>
<p class="MsoNormal" style="mso-hyphenate:none;tab-stops:center
225.65pt"><b style="mso-bidi-font-weight:normal"><span
style="font-size:11.0pt;font-family:
Arial">Full time, fixed term appointment for up to 3 years </span></b><span
style="font-size:11.0pt;font-family:Arial"><o:p></o:p></span></p>
<p class="MsoNormal"><span
style="font-size:11.0pt;font-family:Arial"><o:p> </o:p></span></p>
<p class="MsoNormal"><span
style="font-size:11.0pt;font-family:Arial">We are
seeking a motivated and creative Post Doctoral Researcher (Level
2) to
elucidate inhibition mechanisms of mitotic kinesin motors using
cryo-electron
microscopy. This work is funded by Worldwide Cancer Research and
will be
performed as part of the research team led by Prof Carolyn
Moores.<o:p></o:p></span></p>
<p class="MsoNormal"><span
style="font-size:11.0pt;font-family:Arial"><o:p> </o:p></span></p>
<p class="MsoNormal"><span
style="font-size:11.0pt;font-family:Arial">Inhibitors of
mitotic kinesins block mitosis and are potential cancer
therapies.
Gain-of-function inhibitors specifically block kinesin function
by inducing a
tight microtubule binding state. However, the structures of
these
microtubule-bound inhibitor-blocked motors, and therefore the
precise
inhibition mechanism(s) of these potentially important
molecules, are not known.
The goal of this project is to determine these mechanisms of
mitotic kinesin
inhibition using state-of-the-art cryo-electron microscopy
structure
determination and molecular modeling. <span style="color:black">The
appointee
will be a member of a team working on regulatory mechanisms of
cytoskeleton
dynamics (</span><a
href="http://people.cryst.bbk.ac.uk/%7Eubcg62d/">http://people.cryst.bbk.ac.uk/~ubcg62d/</a>)<span
style="color:black"> and will interact with members of the
Birkbeck Electron
Microscopy group.<o:p></o:p></span></span></p>
<p class="MsoNormal"><span
style="font-size:11.0pt;font-family:Arial;color:black"><o:p> </o:p></span></p>
<p class="MsoNormal"><span
style="font-size:11.0pt;font-family:Arial;color:black">The
</span><span
style="font-size:11.0pt;font-family:Arial;mso-ansi-language:
EN-US" lang="EN-US">Birkbeck EM lab is located in an
outstanding, collaborative environment
for structural, molecular and cellular biology, in the
Crystallography section
of the Department of Biological Sciences, which forms part of
the joint
Institute for Structural and Molecular Biology with University
College London.
The EM lab is equipped with a 300 kV Polara microscope and a 200
kV FEG system
with K2 and DE20 direct electron detectors, and 120 kV and 100
kV cryo
microscopes, as well as sample preparation equipment for single
particles, high
pressure freezing, vitrified sections and freeze substitution.<o:p></o:p></span></p>
<p class="MsoNormal"><span
style="font-size:11.0pt;font-family:Arial;
mso-ansi-language:EN-US" lang="EN-US"><o:p> </o:p></span></p>
<p class="MsoNormal"
style="text-align:justify;text-justify:inter-ideograph"><span
style="font-size:11.0pt;font-family:Arial;color:black;layout-grid-mode:line">Applicants
should
have a PhD in structural biology, biochemistry or a related
area, and
have relevant research publications.<o:p></o:p></span></p>
<p class="MsoBodyText"><b><span
style="mso-bidi-font-size:11.0pt;font-family:
Arial;mso-ansi-language:EN-GB"><o:p> </o:p></span></b></p>
<p class="MsoNormal"><b style="mso-bidi-font-weight:normal"><span
style="font-size:11.0pt;font-family:Arial;color:black">Salary:</span></b><span
style="font-size:11.0pt;font-family:Arial;color:black"> Grade 7
of the
College’s London Pay Scale, which is £36,150 to £41,318 per
annum, depending on
experience.<o:p></o:p></span></p>
<p class="MsoNormal"><span
style="font-size:11.0pt;font-family:Arial;color:black"><o:p> </o:p></span></p>
<p class="MsoNormal"><span
style="font-size:11.0pt;font-family:Arial">This is a
full-time and fixed term position for up to three years. The
appointment may be
subject to a probationary period of twelve months. Birkbeck also
provides a
generous final salary pension scheme, 31 days paid leave,
flexible working
arrangements and other great benefits. <o:p></o:p></span></p>
<p class="MsoNormal"><span
style="font-size:11.0pt;font-family:Arial"><o:p> </o:p></span></p>
<p class="MsoNormal"><span
style="font-size:11.0pt;font-family:Arial;
mso-ansi-language:EN-US" lang="EN-US">For details and
application forms, please see:<u1:p></u1:p></span><span
style="font-size:11.0pt;font-family:Arial" lang="EN-US"> </span><span
style="font-size:11.0pt;font-family:Arial;color:#1F497D"><a
href="http://tinyurl.com/z7vc66t">http://tinyurl.com/z7vc66t</a></span><span
style="font-size:11.0pt;font-family:Arial"><o:p></o:p></span></p>
<p class="MsoNormal"><b><span
style="font-size:11.0pt;font-family:Arial"><o:p> </o:p></span></b></p>
<p class="MsoNormal"><b><span
style="font-size:11.0pt;font-family:Arial">The
closing date for completed applications is midnight on April 7<sup>th</sup>,
2016</span></b><span
style="font-size:11.0pt;font-family:Arial"><o:p></o:p></span></p>
<p class="MsoNormal"><b><span
style="font-size:11.0pt;font-family:Arial;
color:black">Interviews will be held early May</span></b><span
style="font-size:11.0pt;font-family:Arial;color:black"><o:p></o:p></span></p>
<p class="MsoNormal"><span
style="font-size:11.0pt;font-family:Arial;color:black"> <o:p></o:p></span></p>
<p class="MsoNormal"><span
style="font-size:11.0pt;font-family:Arial">Informal
enquiries can be made to Carolyn Moores
(<a class="moz-txt-link-abbreviated" href="mailto:c.moores@mail.cryst.bbk.ac.uk">c.moores@mail.cryst.bbk.ac.uk</a>)<span style="color:black"><o:p></o:p></span></span></p>
<p class="MsoNormal"><span
style="font-size:11.0pt;font-family:Arial"><o:p> </o:p></span></p>
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