[3dem] Postdoc job at Birkbeck College, London

Carolyn Moores c.moores at mail.cryst.bbk.ac.uk
Thu Jun 23 10:56:05 PDT 2016

Dear colleagues

*Institute of Structural and Molecular Biology, Birkbeck College, London*

*Department of Biological Sciences*


*Post Doctoral Researcher - Structural Biology(Ref: 11905)*

*Full time, fixed term appointment for up to 3 years *

We are seeking a motivated and creative Post Doctoral Researcher (Level 
2) to dissect the molecular properties of malaria kinesins required for 
parasite replication using cryo-electron microscopy. This work is funded 
by Biotechnology and Biological Sciences Research Council (BBSRC) and 
will be performed as part of the research team led by Prof Carolyn Moores.

Kinesins are a large superfamily of ATP-driven, microtubule-based 
motors. They perform a variety of essential functions in eukaryotic 
replication, but their roles in malaria replication are poorly 
understood. The goal of this project is to apply state-of-the-art 
cryo-EM methods to visualise the mechanistic basis of malaria kinesin 
function. We will combine these structural studies with biophysical 
characterisation to evaluate their motile properties. This project will 
also be performed in close collaboration with the group of Professor 
Rita Tewari (University of Nottingham, http://www.tewarilab.co.uk), an 
expert in /Plasmodium/ cell biology, providing crucial in vivo context 
for our in vitro studies. The appointee will be a member of a team 
working on regulatory mechanisms of cytoskeleton dynamics 
<http://people.cryst.bbk.ac.uk/%7Eubcg62d/>) and will interact with 
members of the Birkbeck Electron Microscopy group 
<http://people.cryst.bbk.ac.uk/%7Eubcg16z/empage.html>). This project 
presents unique opportunities to study kinesins from evolutionarily 
divergent organisms, thereby illuminating novel motor properties and 
regulatory mechanisms in cell division.

The Birkbeck EM lab is located in an outstanding, collaborative 
environment for structural, molecular and cellular biology, in the 
Crystallography section of the Department of Biological Sciences, which 
forms part of the joint Institute for Structural and Molecular Biology 
(ISMB) with University College London. The EM lab is equipped with a 300 
kV Polara microscope and a 200 kV FEG system with K2 and DE20 direct 
electron detectors, and 120 kV and 100 kV cryo microscopes, as well as 
sample preparation equipment for single particles, high pressure 
freezing, vitrified sections and freeze substitution.

Applicants should have a PhD in structural biology, biochemistry or a 
related area, and have relevant research publications.


For details and application forms, please see: http://tinyurl.com/zrbaj95


*The closing date for completed applications is midnight on July 31^st , 

*Interviews will be held mid-August*

Informal enquiries can be made to Carolyn Moores 
(c.moores at mail.cryst.bbk.ac.uk <mailto:c.moores at mail.cryst.bbk.ac.uk>)

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