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<p class="MsoNormal"><span
style="font-size:11.0pt;font-family:Arial;mso-fareast-font-family:
"Times New Roman"">Dear colleagues<o:p></o:p></span></p>
<p class="MsoNormal"><span
style="font-size:11.0pt;font-family:Arial;mso-fareast-font-family:
"Times New Roman""><o:p> </o:p></span></p>
<p class="MsoNormal" style="mso-outline-level:5"><b><span
style="font-size:11.0pt;font-family:Arial;mso-ansi-language:EN-US"
lang="EN-US">Institute of
Structural and Molecular Biology, Birkbeck College, London</span></b><span
style="font-size:11.0pt;font-family:Arial"><o:p></o:p></span></p>
<p class="MsoNormal" style="mso-outline-level:5"><b
style="mso-bidi-font-weight:
normal"><span
style="font-size:11.0pt;font-family:Arial;mso-fareast-font-family:
"Times New Roman"">Department of Biological Sciences</span></b><span
style="font-size:11.0pt;font-family:Arial"><o:p></o:p></span></p>
<p class="MsoNormal"><b style="mso-bidi-font-weight:normal"><span
style="font-size:11.0pt;font-family:Arial;layout-grid-mode:line"> </span></b><span
style="font-size:11.0pt;font-family:Arial"><o:p></o:p></span></p>
<p class="MsoNormal" style="mso-hyphenate:none;tab-stops:center
225.65pt"><b style="mso-bidi-font-weight:normal"><span
style="font-size:11.0pt;font-family:
Arial">Post Doctoral Researcher - Structural Biology<span
style="mso-bidi-font-weight:
bold"> </span>(Ref: 11905)</span></b><span
style="font-size:11.0pt;font-family:
Arial"><o:p></o:p></span></p>
<p class="MsoNormal" style="mso-hyphenate:none;tab-stops:center
225.65pt"><b style="mso-bidi-font-weight:normal"><span
style="font-size:11.0pt;font-family:
Arial">Full time, fixed term appointment for up to 3 years </span></b><span
style="font-size:11.0pt;font-family:Arial"><o:p></o:p></span></p>
<p class="MsoNormal"><span
style="font-size:11.0pt;font-family:Arial"><o:p> </o:p></span></p>
<p class="MsoNormal"><span
style="font-size:11.0pt;font-family:Arial;mso-fareast-font-family:
"Times New Roman"">We are seeking a motivated and
creative Post Doctoral
Researcher (Level 2) to dissect the molecular properties of
malaria kinesins
required for parasite replication using cryo-electron
microscopy. This work is
funded by Biotechnology and Biological Sciences Research Council
(BBSRC) and
will be performed as part of the research team led by Prof
Carolyn Moores.</span><span
style="font-size:11.0pt;font-family:Arial"><o:p></o:p></span></p>
<p class="MsoNormal"><span
style="font-size:11.0pt;font-family:Arial"> <o:p></o:p></span></p>
<p class="MsoNormal"><span
style="font-size:11.0pt;font-family:Arial;mso-fareast-font-family:
"Times New Roman"">Kinesins are a large superfamily of
ATP-driven,
microtubule-based motors. They perform a variety of essential
functions in
eukaryotic replication, but their roles in malaria replication
are poorly
understood. The goal of this project is to apply
state-of-the-art cryo-EM
methods to visualise the mechanistic basis of malaria kinesin
function. We will
combine these structural studies with biophysical
characterisation to evaluate
their motile properties. This project will also be performed in
close
collaboration with the group of Professor Rita Tewari
(University of
Nottingham, <a href="http://www.tewarilab.co.uk">http://www.tewarilab.co.uk</a>),
an
expert in <i style="mso-bidi-font-style:normal">Plasmodium</i>
cell biology,
providing crucial in vivo context for our in vitro studies. The
appointee will
be a member of a team working on regulatory mechanisms of
cytoskeleton dynamics
(<a href="http://people.cryst.bbk.ac.uk/%7Eubcg62d/">http://people.cryst.bbk.ac.uk/~ubcg62d/</a>)
and will interact with members of the Birkbeck Electron
Microscopy group (<a
href="http://people.cryst.bbk.ac.uk/%7Eubcg16z/empage.html">http://people.cryst.bbk.ac.uk/~ubcg16z/empage.html</a>).
This
project presents unique opportunities to study kinesins from
evolutionarily
divergent organisms, thereby illuminating novel motor properties
and regulatory
mechanisms in cell division.<o:p></o:p></span></p>
<p class="MsoNormal"><span
style="font-size:11.0pt;font-family:Arial;color:black"> </span><span
style="font-size:11.0pt;font-family:Arial"><o:p></o:p></span></p>
<p class="MsoNormal"><span
style="font-size:11.0pt;font-family:Arial;color:black">The
</span><span
style="font-size:11.0pt;font-family:Arial;mso-ansi-language:
EN-US" lang="EN-US">Birkbeck EM lab is located in an
outstanding, collaborative environment
for structural, molecular and cellular biology, in the
Crystallography section
of the Department of Biological Sciences, which forms part of
the joint
Institute for Structural and Molecular Biology (ISMB) with
University College
London. The EM lab is equipped with a 300 kV Polara microscope
and a 200 kV FEG
system with K2 and DE20 direct electron detectors, and 120 kV
and 100 kV cryo
microscopes, as well as sample preparation equipment for single
particles, high
pressure freezing, vitrified sections and freeze substitution.</span><span
style="font-size:11.0pt;font-family:Arial"><o:p></o:p></span></p>
<p class="MsoNormal"><span
style="font-size:11.0pt;font-family:Arial;
mso-ansi-language:EN-US" lang="EN-US"> </span><span
style="font-size:11.0pt;font-family:
Arial"><o:p></o:p></span></p>
<p class="MsoNormal"
style="text-align:justify;text-justify:inter-ideograph"><span
style="font-size:11.0pt;font-family:Arial;color:black;layout-grid-mode:line">Applicants
should
have a PhD in structural biology, biochemistry or a related
area, and
have relevant research publications.</span><span
style="font-size:11.0pt;
font-family:Arial"><o:p></o:p></span></p>
<p class="MsoNormal"><b><span
style="font-size:11.0pt;font-family:Arial"> </span></b><span
style="font-size:11.0pt;font-family:Arial"> <o:p></o:p></span></p>
<p class="MsoNormal"><span
style="font-size:11.0pt;font-family:Arial;
mso-ansi-language:EN-US" lang="EN-US">For details and
application forms, please see: </span><span
style="font-size:11.0pt;font-family:Arial;mso-fareast-font-family:"Times
New Roman";
color:#1F497D"><a href="http://tinyurl.com/zrbaj95">http://tinyurl.com/zrbaj95</a></span><span
style="font-size:11.0pt;font-family:Arial;mso-ansi-language:EN-US"
lang="EN-US"><o:p></o:p></span></p>
<p class="MsoNormal"><b><span
style="font-size:11.0pt;font-family:Arial"> </span></b><span
style="font-size:11.0pt;font-family:Arial"><o:p></o:p></span></p>
<p class="MsoNormal"><b><span
style="font-size:11.0pt;font-family:Arial">The
closing date for completed applications is midnight on July 31<sup>st</sup>,
2016</span></b><span
style="font-size:11.0pt;font-family:Arial"><o:p></o:p></span></p>
<p class="MsoNormal"><b><span
style="font-size:11.0pt;font-family:Arial;
color:black">Interviews will be held mid-August</span></b><span
style="font-size:11.0pt;font-family:Arial"><o:p></o:p></span></p>
<p class="MsoNormal"><span
style="font-size:11.0pt;font-family:Arial;color:black"> </span><span
style="font-size:11.0pt;font-family:Arial"><o:p></o:p></span></p>
<p class="MsoNormal"><span
style="font-size:11.0pt;font-family:Arial">Informal
enquiries can be made to Carolyn Moores (<a
href="mailto:c.moores@mail.cryst.bbk.ac.uk">c.moores@mail.cryst.bbk.ac.uk</a>)<o:p></o:p></span></p>
<p class="MsoNormal"><span
style="font-size:11.0pt;font-family:Arial"><o:p> </o:p></span></p>
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