[3dem] Post-doctoral position at MRC LMB

[Lori Passmore]

Post-doctoral position at MRC Laboratory of Molecular Biology

A postdoctoral position is available in my group to study the Fanconi Anaemia (FA) core complex, a large multisubunit E3 ubiquitin ligase involved in DNA repair (see Rajendra et al 2014). We aim to understand the mechanistic basis of substrate ubiquitination by FA core complex. The candidate will determine high-resolution cryo-EM structures of relevant complexes. This work will be combined with functional studies to determine the molecular mechanisms of the complex in vivo and in vitro.

Members of the team use a hybrid approach including electron microscopy, x-ray crystallography, genetics and biochemistry. The ideal candidate will have experience in structural biology (preferably electron microscopy). 

For more information about our research, visit our website :
http://www2.mrc-lmb.cam.ac.uk/groups/passmore/Home.html
Please contact me for informal enquires and apply through the MRC website:
https://mrc.tal.net/vx/lang-en-GB/appcentre-1/candidate/postings/26


References: 
Rajendra E, Oestergaard VH, Langevin F, Wang M, Dornan GL, Patel KJ & Passmore LA (2014) The genetic and biochemical basis of FANCD2 monoubiquitination. Mol Cell 54(5): 858-869. 

Rajendra E, Garaycoechea JI, Patel KJ & Passmore LA (2014) Abundance of the Fanconi anaemia core complex is regulated by the RuvBL1 and RuvBL2 AAA+ ATPases. Nucleic Acids Research 42(22):13736-48

Russo CJ & Passmore LA (2014) Ultrastable gold substrates for electron cryomicroscopy. Science 346(6215):1377-1380


Thank you,

Lori Passmore
MRC Laboratory of Molecular Biology
Francis Crick Avenue, Cambridge, CB2 0QH
Tel: (+44) 1223 26 7062

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