[3dem] Position opening: Cryo-EM at Pfizer (Groton, CT)

[Han, Seungil]

All,

Pfizer Structural Biology group (Groton, CT) has a job opening for cryo-EM and the candidate can apply the job in the link below.

https://www.linkedin.com/jobs2/view/externalApply/38632510?url=http%3A

Senior Scientist, Structural Biology- cryo-EM
Role Description
The successful candidate will join the department of Groton Structural Biology and Biophysics (SB&B), a multidisciplinary group with established expertise in molecular biology, protein biochemistry, biological mass spectrometry, proteomics, enzymology, NMR, biophysics and crystallography. Our mission is to provide integrated molecular insights into drug target mechanism and target-ligand interactions to promote discovery efforts across multiple therapeutic areas, including Inflammation and Immunology, Neuroscience, Cardiovascular, Metabolic & Endocrine Diseases, Pain, Rare Diseases and Oncology.

As a Senior Scientist, you will have experience with all aspects of structure determination by cryo-EM technology including sample preparation, data collection, data processing using state-of-art software, and 3-D reconstruction. Ideally you will also be familiar with the hardware associated with EM data collection such as microscope, direct electron detector, sample robot etc. and their maintenance. Equally important will be your ability to collaborate successfully with other scientists in the department and with biologists and chemists in multiple drug discovery teams. You will eventually be expected to understand the critical issues and challenges faced by different drug discovery programs within Pfizer and design suitable experimental strategies based on cryo-EM technique that could positively impact the outcomes. SB&B is part of Worldwide Medicinal Chemistry group within Pfizer, with the overall goal of understanding the mode of action of lead compound using an integrated assessment of all aspects of protein-ligand interactions to drive drug discovery efforts.

Responsibilities
The Senior Scientist will design and perform experiments in the technical area of single particle cryo-EM. Experimental results will be formulated computationally and will be recorded in an electronic laboratory notebook.
Prompt and clear communication will occur with project team colleagues. External scientific publication and presentation will be encouraged when appropriate as a means of assuring optimal research standards.

Qualifications
Education & Experience:
*Doctoral degree or equivalent in Biochemistry, Biophysics, Physics, Chemistry or related field
*Postdoctoral training in cryo-EM with ca. 2-5 years of industrial or related academic experience
*Broad knowledge of biology and molecular techniques in protein science and chemistry are also desirable

Technical Skills Requirements:
Proven ability to design and conduct state-of-the-art single particle cryo-EM experiments, leading to a strong track record of successful outcomes with publications in leading journals. Has the skill and drive to grow into a thought leader in this field.

Familiar with protein characterization, biophysical, structural and computational techniques to facilitate problem-solving.

******************************************
Seungil Han, Ph.D.
Pfizer Inc.
Eastern Point Road, MS 8220-3266
Groton, CT 06340
Tel: 860-686-1788
Email: seungil.han at pfizer.com

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