[3dem] INSTRUCT course on Computational Tools Combining Atomic and Volume Data

[Tom Burnley]

Instruct with CCP-EM is proud to announce the following workshop:

'INSTRUCT course on Computational Tools Combining Atomic and Volume Data'

* Event Details
There is increasing overlap between structural biology disciplines, a
common example being the interpretation of volume data from electron
cryo-microscopy (cryoEM) in terms of atomic models from crystallography
(MX) and nuclear magnetic resonance spectroscopy (NMR). A wide variety of
tools exist to perform rigid-body or flexible fitting. If docking of models
is successful, then one can obtain atomistic detail of large
multi-component complexes, leading to a better understanding of cellular
machinery.

However, because of the limited resolution of cryoEM volumes, fitting of
atomic models is not straightforward, and there is a strong danger of
overfitting. The course will give an overview of the issues involved, an
introduction to selected tools from the cryoEM, MX and NMR fields, and a
discussion of validation. There will be a mixture of lectures and hands-on
practicals. The course will highlight software available from CCISB
partners.

The course is aimed at both electron microscopists wishing to interpret
their volume models, and scientists from MX/NMR looking to understand the
increasing amount of cryoEM data available. The course is open to
investigators at all levels, but participants should have collected, or be
close to collecting, relevant structural data. We will work with examples
from the PDB and EMDB, but participants can bring their own data to look at
if they wish.

The course is limited to 20 delegates which will be selected from all
applicants.  A maximum of 60 applicants can register interest.

Applications will close on Friday 20th February and the 20 successful
applicants will be notified by 2nd March.

* For more information:

https://www.structuralbiology.eu/support/whats-on/calendar-events/computational-tools-combining-atomic-and-volume-data

* For registration:

https://eventbooking.stfc.ac.uk/news-events/instruct-course--on-computational-tools-combining-atomic-and-volume-data-263

* Confirmed tutors:

Maya Topf (Birkbeck)
Alan Roseman (Manchester)
Garib Murshudov (MRC-LMB Cambridge)
Paul Emsley (MRC-LMB Cambridge)
Agnel Praveen Joseph (STFC)
Ardan Patwardhan (EBI)
Stuart McNicholas (York)

Best wishes,

Tom & Martyn


-- 
Dr Tom Burnley, PhD
Science and Technology Facilities Council (STFC)
The Research Complex At Harwell
Rutherford Appleton Laboratory, R92
OX11 0FA
01235 56 7871
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