[3dem] Hybrid Methods in Structural Biology March 4-8, 2015 - Scholarship and Discounted Abstract Deadline is Nov 6, 2014

Jens Meiler jens at meilerlab.org
Tue Nov 4 09:55:37 PST 2014


The "Hybrid Methods in Structural Biology" is scheduled for March 4—8, 2015,
Granlibakken Resort, Tahoe City, California, USA. I write to you today  as
the Scholarship and Discounted Abstract Deadline is the day after tomorrow
(Nov 6, 2014). The meeting website is http://www.keystonesymposia.org/15C2 .
We will provide ample opportunity for students and post-doctoral fellow to
give oral presentations. We also training workshops for Rosetta organized by
the Meiler Lab and IMP organized by the Sali Lab. 'At poster presentations'
for novel computational approaches in hybrid methods will be possible.
Please forward to interested colleagues, students, e-mail list. We look
forward to meeting many of you at Lake Tahoe, 


Scholarship Deadline: Nov 6, 2014
Discounted Abstract Deadline: Nov 6, 2014 
Abstract Deadline: Dec 9, 2014
Discounted Registration Deadline: Jan 8, 2015

Ad Bax, NIDDK, National Institutes of Health, USA
Richard Neutze, University of Gothenburg, Sweden
Christian Betzel, University of Hamburg, Germany
Stefan Raunser, Max Planck Institute of Molecular Physiology, Germany
Karen G. Fleming, Johns Hopkins University, USA
Leo Sazanov, Medical Research Council, UK
Jens Meiler, Vanderbilt University, USA
Mei Hong, Iowa State University, USA
Gunnar Jeschke, ETH Zürich, Switzerland
Judy E. Kim, University of California San Diego, USA
Yifan Cheng, University of California, San Francisco, USA
Patrick Cramer, University of Munich (LMU), Germany
Nenad Ban, ETH Zürich, Switzerland
Juli Feigon, University of California, Los Angeles, USA
Martin Beck, European Molecular Biology Laboratory, Germany
Sarah Teichmann, EMBL-EBI, UK
Nikolaos G. Sgourakis, NIDDK, National Institutes of Health, USA
Rudolf H. Aebersold, Institute of Molecular Systems Biology, ETH Zürich,
Elizabeth Villa, University of California, San Diego, USA
Frank DiMaio, University of Washington, USA

As we study the structure and dynamics of more and more complex systems to
better understand their biological function, each individual technology in
the structural biology toolbox approaches its limitations. These limitations
include size of the system, timeline of motions, spatial and/or temporal
resolution, and ensemble averaging. Further, each individual method perturbs
the system in a different way to enable or facilitate its analysis. This
includes for example the introduction of spin labels to perform EPR
experiments, the reconstitution of membrane proteins in micelles for NMR
spectroscopy, the introduction of entire domains to stabilize proteins in
certain conformations for crystallization, or a simplified force field in
computation. As systems become more challenging, the perturbations tend to
get more drastic, complicating the interpretation of results. Only at the
intersection of several techniques it becomes possible to distinguish
information that is biologically relevant from perturbations introduced by
any individual approach. Moving forward, hybrid methods and integrated
methods in structural biology play a key role in studying complex systems
verifying each other’s results. The objective of this meeting is two-fold:
1) To discuss novel and potentially disruptive technologies and/or
combinations thereof to be added to the hybrid methods toolbox; and 2) To
illustrate and discuss application of hybrid methods to important biological
systems. These objectives will be achieved not only by a line-up of
exceptional oral presentations, but also by a prominently placed poster
session, discussions in panel format, and tutorial sessions introducing new
software algorithms.


Jens Meiler, Ph.D.
Associate Professor
Vanderbilt University
Departments of Chemistry, Pharmacology, and Biomedical Informatics Center
for Structural Biology, Institute for Chemical Biology


office: MRBIII, Room 5144 B, 465 21st Ave South, Nashville, TN 37232 
mail  : 7330 Stevenson Center, Station B 351822, Nashville, TN 37235
e-mail: jens at meilerlab.org
URL   : www.meilerlab.org
Phone : +1 (615) 936-5662
Phone : +1 (615) 936-2209 (secretary)
Fax   : +1 (615) 936-2211


e-mail: jens at jens-meiler.de
URL   : www.jens-meiler.de


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