[3dem] Postdoctoral positions in structural biology of viral proteins at NIH with Dr. Audray Harris

Harris, Audray (NIH/NIAID) [E] harrisau at mail.nih.gov
Mon Jan 28 12:28:50 PST 2013

Dear Colleagues:


National Institute of Allergy and Infectious Diseases (NIAID), Bethesda, MD and surrounding area

The Structural Informatics Unit (SIU) seeks to elucidate the molecular architecture, function, and epitope diversity of viral proteins. The research program exploits 3D electron microscopy of viruses and protein complexes to obtain structural information. Structural analyses are supported by other structural, biochemical, and immunological analyses in order to understand antigen-antibody interactions and aid in both structure-assisted immunogen and therapeutic designs for infectious diseases.  Our research program integrates structural and biochemical studies with bioinformatics to facilitate a collaborative synergy between these disciplines in the context of the focus on structure-function studies of viruses and viral proteins.  A major focus is on the antigenicity, structure, and function of respiratory viruses, such as influenza.

We are looking for candidates who can work collaboratively on problems related to virus structure, assembly, and antigenicity and have a strong background in at least one of these areas: structural biology (cryo-electron microscopy or x-ray crystallography), computational biology/image or data processing or virology and protein biochemistry.
For more information, see recent publications and below:

(website under construction)

Harris, A. et al. (2013). Structure and accessibility of HA trimers on intact 2009 H1N1 pandemic influenza virus tostem region-specific neutralizing antibodies. Proc Natl Acad Sci U S A (in press).
Harris, A. et al. (2011) Trimeric HIV-1 glycoprotein gp140 immunogens and native HIV-1 envelope glycoproteins display the same closed and open quaternary molecular architectures. Proc Natl Acad Sci U S A 108, 11440-5.


Applicants must have a Ph.D., or M.D., or equivalent, and less than 5 (preferably have less than 2) years of postdoctoral experience. The Structural Informatics Unit of the Laboratory of Infectious Diseases is located on the main NIH campus. The NIH is dedicated to building a diverse community in its training and employment programs.

To Apply:
Candidates should submit a CV, and a one-page research experience summary describing research accomplishments, and contact information for three letters of reference. Please write "Postdoctoral application" in the subject header and send to:

Audray K. Harris, Ph.D.
Head, Structural Informatics Unit
Laboratory of Infectious Diseases
National Institute of Allergy and Infectious Diseases
National Institutes of Health
50 South Drive, Room 6351, MSC 8005
Bethesda, MD 20892-8005 USA
email: harrisau at mail.nih.gov

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