[3dem] SIMPLE 2.0 released

[Hans Olof Elmlund]

Dear Colleagues:

We hereby announce the release of SIMPLE 2.0. The common lines-based routines have been replaced 
with a new probabilistic image alignment algorithm PRIME (Probabilistic Initial 3D Model Generation 
for Single-Particle Cryo-Electron Microscopy) that was presented on the 3DEM Gordon conference. The 
article is available at http://www.sciencedirect.com/science/article/pii/S0969212613002505 and the 
software can be downloaded at http://simple.stanford.edu/. The SIMPLE 2.0 distribution currently 
contains the starting model generation procedure (PRIME), a clustering algorithm, and a bunch of
utility programs. Improved algorithms for heterogeneity analysis and refinement are underway.

Happy Processing!

Hans & Dominika

-- 
Hans Elmlund
Postdoctoral Fellow
Roger Kornberg Laboratory
Dept. of Structural Biology
Stanford University School of Medicine
Fairchild Bldg - 1st floor, D117
299 Campus Dr.,
Stanford CA, 94305-5126
USA
phone: 650 284 63 19
e-mail: hael at stanford.edu