[3dem] Postdoctoral positions in Cryo-EM

Joachim Frank jf2192 at columbia.edu
Mon Aug 12 08:26:35 PDT 2013


Two postdoctoral positions are available immediately in the laboratory
of Dr. Joachim Frank at the Department of Biochemistry and Molecular
Biophysics, Columbia University, New York.

Applications will be considered from highly motivated individuals with a
Ph.D. degree in the Natural Sciences. Preference will be given to
applicants with demonstrated expertise in one of the following areas:
experimental or computational aspects of cryo-electron microscopy,
signal processing, RNA modeling.

The Frank Lab (http://franklab.cpmc.columbia.edu/) conducts in-depth
research on the mechanism of protein synthesis in bacteria and eukaryotes,
using single-particle cryo-EM of in vitro samples. Three-dimensional
density maps reconstructed in this way are interpreted by flexible fitting,
homology modeling of proteins, and  ab initio modeling of RNAs. By using
classification of heterogeneous samples, multiple states of equilibrating
molecular complexes can be characterized.

The research is supported by the Howard Hughes Medical Institute and grants
by the National Institute of Health.

  The EM facility in the Frank Lab, situated on the Medical Campus, has a
300-kV FEI Tecnai Polara microscope equipped with a K2 Summit Gatan 4k x 4k
camera, capable of single-electron counting, and a 200-kV FEI Tecnai
with a Gatan 4k x 4k CCD camera. Equipment for time-resolved cryo-EM
using microfluidic nanochips with a minimum of 10 ms reaction time is
available. Additional electron microscopes and supporting facilities
such as focused ion-beam milling and high-pressure freezing are
available at the New York Structural Biology Center, a nearby Resource
Center supported by a Consortium of Universities that Columbia
University is part of.

Qualified applicants should send CV, including the names of three
references, and a statement of career goals to Masgan Saidi
(ms4597 at columbia.edu), Biochemistry and Molecular Biophysics,  Columbia
University, Black Building 2-221, 650 West 168th Street,  New York, NY
10032.






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