[3dem] Postdoctoral Positions in Cryo-EM

Joachim Frank jf2192 at columbia.edu
Wed Oct 31 08:20:04 PDT 2012

*Two postdoctoral positions are available immediately in the laboratory 
of Dr. Joachim Frank at the Department of Biochemistry and Molecular 
Biophysics, Columbia University, New York. *

Applications will be considered from highly motivated individuals with a 
Ph.D. degree in the Natural Sciences. Preference will be given to 
applicants with demonstrated expertise in experimental or computational 
aspects of cryo-electron microscopy.

The Frank Lab conducts in-depth research on the mechanism of protein 
synthesis in bacteria and eukaryotes, using single-particle cryo-EM of 
/in vitro/ samples, as well as electron tomography of cell 
sections.Three-dimensional density maps reconstructed are interpreted by 
flexible fitting, homology modeling of proteins, and /ab initio 
/modeling of RNAs.By using classification of heterogeneous samples, 
multiple states of equilibrating molecular complexes are characterized.

The EM facility in the Frank Lab, situated on the Medical Campus, has a 
300-kV FEI Tecnai Polara microscope equipped with a K2 Gatan 4k x 4k 
camera, capable of single-electron counting, and a 200-kV FEI Tecnai 
with a Gatan 4k x 4k CCD camera. Equipment for time-resolved cryo-EM 
using microfluidic nanochips with a minimum of 10 ms reaction time is 
available. Additional electron microscopes and supporting facilities 
such as focused ion-beam milling and high-pressure freezing are 
available at the New York Structural Biology Center, a nearby Resource 
Center supported by a Consortium of Universities that Columbia 
University is part of.

Qualified applicants should send CV, including the names of three 
references, and a statement of career goals to Dr. Joachim Frank, HHMI, 
Professor of Biochemistry and Molecular Biophysics, Columbia University, 
Black Building 2-221, 650 West 168^th Street, New York, NY 
10032.Alternatively, correspondence may be addressed via email to Masgan 
Saidi (ms4597 at columbia.edu) and cc'ed to jf2192 at columbia.edu 
<mailto:jf2192 at columbia.edu>.

Joachim Frank, Ph.D.
Howard Hughes Medical Institute Investigator,
Professor, Department of Biochemistry and Molecular Biophysics,
and Department of Biology, Columbia University,
650 W. 168th Street, P&S Black Building 2-221
New York, NY10032
(T) 212 305-9510
(F) 212 305-9500
(E) jf2192 at columbia.edu

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