[3dem] Postdoctoral Positions in Cryo-EM
jf2192 at columbia.edu
Wed Oct 31 08:20:04 PDT 2012
*Two postdoctoral positions are available immediately in the laboratory
of Dr. Joachim Frank at the Department of Biochemistry and Molecular
Biophysics, Columbia University, New York. *
Applications will be considered from highly motivated individuals with a
Ph.D. degree in the Natural Sciences. Preference will be given to
applicants with demonstrated expertise in experimental or computational
aspects of cryo-electron microscopy.
The Frank Lab conducts in-depth research on the mechanism of protein
synthesis in bacteria and eukaryotes, using single-particle cryo-EM of
/in vitro/ samples, as well as electron tomography of cell
sections.Three-dimensional density maps reconstructed are interpreted by
flexible fitting, homology modeling of proteins, and /ab initio
/modeling of RNAs.By using classification of heterogeneous samples,
multiple states of equilibrating molecular complexes are characterized.
The EM facility in the Frank Lab, situated on the Medical Campus, has a
300-kV FEI Tecnai Polara microscope equipped with a K2 Gatan 4k x 4k
camera, capable of single-electron counting, and a 200-kV FEI Tecnai
with a Gatan 4k x 4k CCD camera. Equipment for time-resolved cryo-EM
using microfluidic nanochips with a minimum of 10 ms reaction time is
available. Additional electron microscopes and supporting facilities
such as focused ion-beam milling and high-pressure freezing are
available at the New York Structural Biology Center, a nearby Resource
Center supported by a Consortium of Universities that Columbia
University is part of.
Qualified applicants should send CV, including the names of three
references, and a statement of career goals to Dr. Joachim Frank, HHMI,
Professor of Biochemistry and Molecular Biophysics, Columbia University,
Black Building 2-221, 650 West 168^th Street, New York, NY
10032.Alternatively, correspondence may be addressed via email to Masgan
Saidi (ms4597 at columbia.edu) and cc'ed to jf2192 at columbia.edu
<mailto:jf2192 at columbia.edu>.
Joachim Frank, Ph.D.
Howard Hughes Medical Institute Investigator,
Professor, Department of Biochemistry and Molecular Biophysics,
and Department of Biology, Columbia University,
650 W. 168th Street, P&S Black Building 2-221
New York, NY10032
(T) 212 305-9510
(F) 212 305-9500
(E) jf2192 at columbia.edu
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