[3dem] BBSRC-funded 4 year PhD studentship at Imperial College London

[Bubeck, Doryen A]

I would like to call your attention to a BBSRC-funded PhD studentship in the lab of Doryen Bubeck at Imperial College London starting October 2013.


Title: Complement-mediated pore formation

The immune complement system in blood kills microbes by making ‘membrane-attack complex’ (MAC) pores in cell membranes. CD59 is a complement regulator that blocks MAC pore formation and protects hosts from bystander damage. Some microorganisms subvert the immune system by hijacking complement regulators to enhance infection. Intermedilysin (ILY) is bacterial toxin that engages CD59 to initiate membrane attachment, the first step in this toxin’s pore formation. The aim of this proposal is to understand a molecular mechanism underlying ILY pore formation and the role CD59 plays in the pathway. Specifically it uses an interdisciplinary approach, integrating structural biology and membrane biophysics, to characterize the assembly of ILY pores in a CD59-decorated liposome model system.

This project is a 4 year BBSRC funded PhD studentship to start October 2013, inclusive of a 1 year Masters in Research and a 3 month Professional Internship for PhDs (PIPS) placement at the Darwin Centre of the Natural History Museum. It is a collaboration between the labs of Doryen Bubeck (Division of Molecular Biosciences), Oscar Ces (Chemistry Department), and Xiaodong Zhang (Division of Molecular Biosciences).

For more details on eligibility and how to apply please see:
http://www3.imperial.ac.uk/bbsrcdoctoraltrainingpartnership

References:
Insights into the action of the superfamily of cholesterol-dependent cytolysins from studies of intermedilysin. Polekhina G, Giddings KS, Tweten RK, Parker MW.
Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):600-5.

Mapping the intermedilysin-human CD59 receptor interface reveals a deep correspondence with the binding site on CD59 for complement binding proteins C8alpha and C9. Wickham SE, Hotze EM, Farrand AJ, Polekhina G, Nero TL, Tomlinson S, Parker MW, Tweten RK. J Biol Chem. 2011 Jun 10;286(23):20952-62.
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Doryen Bubeck
Lecturer in Structural Biology
Imperial College London
Division of Molecular Biosciences
602 Sir Ernst Chain Building
South Kensington, London, SW7 2AZ
(0) 207 594 2989
d.bubeck at imperial.ac.uk
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