[3dem] PCS vs cryoEM

[Kimberley Cheng]

Dear all,

I recently got the following question "The particle size of our liposome product determined by cryoEM is about 75 nm, but the particle size determined by photon correlation spectroscopy (PCS) is about 110 nm. So we were wondering why the size determined by cryoEM is smaller than by PCS method?".

Does anyone have a good explanation to this?

Many thanks in advance!
/Kimberley

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