[3dem] Postdoc positions available

[Zheng H Liu]

Calcium release channel: structure and conformational dynamics

A postdoctoral research position is available to work on an NIH funded
project (4 years) to study the structure and conformational dynamics of
ryanodine receptor/calcium release channel.  High resolution cryo-electron
microscopy and computational image processing, in conjunction with confocal
laser scanning microscopy and fluorescence resonance energy transfer
techniques, are being used to determine the three-dimensional structure of
ryanodine receptors, and to characterize their conformation dynamics. We
are particularly interested in the defective interactions between ryanodine
receptor's structural domains and between the receptor and its modulators
that physiologically regulate channel functions, and in the abnormal
conformational changes that underlie dysfunction of ryanodine receptors.
The information will help us to understand the role of ryanodine receptors
in excitation-contraction coupling mechanisms, and how the dysfunction of
ryanodine receptors leads to cardiac muscle diseases, which in turn may
allow rational design of novel therapeutic strategies.

We are particularly interested in candidates with demonstrated experience
in working with cryo-EM and confocal fluorescent microscopy.  The Resource
for the Visualization of Biological Complexity at the Wadsworth Center is a
federally supported national biotechnological resource, the Resource is
fully equipped for all aspects of cryo-EM (see
http://www.wadsworth.org/rvbc/index.html for more detail). The Advanced
Light Microscopy and Image Analysis Core also has a state-of-the-art
fluorescent microscopy facility (please see
http://www.wadsworth.org/cores/alm/index.htm)

Applications, including names and email address of at least three
references, should be sent to:
Zheng Liu, Ph.D.
Wadsworth Center
New York State Department of Health
Empire State Plaza,
Box 509
Albany, NY 12201-0509

Phone: 518-486-2712; Fax: 518-474-7992
Email: zhl01 at health.state.ny.us
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