[3dem] Postdoctoral Position in Single Particle Studies of the Nuclear Pore Complex

David Stokes stokes at nyu.edu
Thu Jul 22 15:26:45 PDT 2010


Postdoctoral Position in Single Particle Studies of the Nuclear Pore Complex

A postdoctoral position is open at the New York Structural Biology 
Center (NYSBC) to study macromolecular assemblies forming part of the 
nuclear pore complex. These studies are part of the National Center for 
Dynamic Interactome Research (NCDIR) a transcontinental effort on 
bioinformatics to elucidate form and function of biologically important 
organelles, using a combination of biochemical data, mass spectrometry, 
X-ray crystallography, nuclear magnetic resonance and electron 
microscopy (http://www.ncdir.org). In addition to staff at NYSBC (Ruben 
Diaz), this collaboration includes laboratories at Rockefeller 
University (Michael Rout and Brian Chait), Institute for Systems 
Biology, Seattle (John Aitchison) and University of California, San 
Francisco (Andrej Sali).

At NYSBC, we aim to characterize the macromolecular assemblies by single 
particle electron microscopy.  The assemblies tend to be small and 
available in small quantities, but even 2D class averages are proving 
valuable as holonomic constraints in the force fields used for modeling 
the structure of the entire nuclear pore complex. In favorable cases, 3D 
reconstructions will be conducted using random conical tilt methods.

Preference will be given to candidates familiar with single particle 
analysis and with a strong interest in the experimental aspects of 
electron microscopy. The position is funded for a period of 5 years and 
will be based at the New York Structural Biology Center, which is a 
state of the art cryo-electron microscopy facility located on the island 
of Manhattan (http://cryoem.nysbc.org). Please send application 
materials to David Stokes (stokes at nysbc.org) with a CV and the names of 
three references.

-- 
David L. Stokes
Skirball Institute, NYU Medical Center
tel: 212-263-1580
http://saturn.med.nyu.edu/~stokes
----
New York Structural Biology Center
tel: 212-939-0660 x9116
http://nysbc.org/
fax: 646-219-0300




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