[3dem] Postdoctoral position for biologist on 3-Dimensional Scanning Transmission Electron Microscopy

[Niels de Jonge]

Postdoctoral position for biologist on 3-Dimensional Scanning Transmission
Electron Microscopy

The group of Prof. Niels de Jonge has a postdoctoral position available in
the Department of Molecular Physiology and Biophysics at the Vanderbilt
University Medical Center (VUMC).  Co-supervisor will be Prof.  Jay Jerome
of the Department of Pathology.  We are developing 3D STEM, a novel method
for obtaining three-dimensional structural information about biological
samples.  The technology is based on the principles of confocal microscopy
but provides higher resolution with the use of electron microscopy.  3D STEM
is a unique alternative for electron tomography with potentially improved
capabilities.  The project is a collaboration between VUMC and Oak Ridge
National Laboratory (ORNL) and uses the aberration corrected microscopes at
ORNL.  Funding is provided by the National Institute of Health through a
4-year R01 project.

We have already demonstrated a resolution comparable to tilt-series
transmission electron tomography and we are now working to improve the
imaging capabilities even further.  A key question is to determine the range
of samples suitable for 3D STEM and how best to prepare these samples.  We
are investigating, for example, the potential of 3D STEM to image whole
cells.  The open position focuses on the development of new sample
preparation methods optimized for 3D STEM, specific protein labeling with
nanoparticles, and, as the project develops, on addressing biomedical
questions with 3D STEM.

The candidate should have a PhD degree in biology, biochemistry, or
equivalent.  Experience with biological sample preparation for electron
microscopy, and with TEM imaging is a plus. Good communication skills in
spoken and written English are essential.

Please send a detailed description of your background and motivation to:
niels.de.jonge at vanderbilt.edu.

More information is on the website:
http://www.ms.ornl.gov/Liquid3DSTEM
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