[3dem] Open postdoctoral positions in biology and biophysics on 3D STEM

Niels de Jonge niels.de.jonge at vanderbilt.edu
Wed Jun 24 20:45:07 PDT 2009


The group of Prof. Niels de Jonge has two postdoctoral positions available
in the Department of Molecular Physiology and Biophysics at the Vanderbilt
University Medical Center (VUMC). Co-supervisor will be Prof. Jay Jerome of
the Department of Pathology. We are developing 3D STEM, a novel method for
obtaining three-dimensional structural information about biological samples.
The technology is based on the principles of confocal microscopy but
provides higher resolution with the use of electron microscopy. 3D STEM is a
unique alternative for electron tomography with potentially improved
capabilities. The project is a collaboration between VUMC and Oak Ridge
National Laboratory (ORNL) and uses the aberration corrected microscopes at
ORNL.
We have already demonstrated a resolution comparable to tilt-series
transmission electron tomography and we are now working to improve the
imaging capabilities even further. A key question is to determine the range
of samples suitable for 3D STEM and how best to prepare these samples. We
are investigating, for example, the potential of 3D STEM to image whole
cells. Funding is provided by the National Institute of Health through a R01
project. 
Our available positions are directed towards two key aspects of the project.
The first position focuses on the development of new sample preparation
methods optimized for 3D STEM and, as the project develops, on addressing
biomedical questions with 3D STEM. The candidate should have a PhD degree in
biology, biochemistry, or equivalent. Experience with biological sample
preparation for electron microscopy, and with TEM imaging is a plus. This
work will be at VUMC.
The second position is on 3D STEM imaging, deconvolution, and data analysis.
The candidate should have a PhD degree in physics, biophysics, computer
science, or equivalent, and have experience with (S)TEM imaging, advanced
data processing, data analysis, and software development. This work with be
performed at ORNL.
Good communication skills in spoken and written English are essential for
both positions.
Please send a detailed description of your background and motivation to:
niels.de.jonge at vanderbilt.edu.
More information is on the website:
http://www.ms.ornl.gov/Liquid3DSTEM

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