[3dem] Postdoctoral Research Position in Biochemistry and Molecular Biology

Clint Potter cpotter at scripps.edu
Fri Dec 18 10:02:25 PST 2009

Postdoctoral Research Position in Biochemistry and Molecular Biology

A postdoctoral position is available immediately (starting date is 
flexible) in the laboratory of Claudio Joazeiro, Department of Cell 
Biology, The Scripps Research Institute (San Diego, California).

Research in the laboratory addresses the function of E3 ubiquitin 
ligases in biology and disease. We have recently made a breakthrough 
finding on the factors involved in the degradation of newly-synthesized 
proteins, using molecular genetic approaches with yeast and mammalian 
cells. The position available is to expand on those findings by carrying 
out biochemical studies that will help elucidate how nascent proteins in 
ribosomes are targeted for ubiquitination. In addition, part of the 
project is to collaborate with the National Resource for Automated 
Molecular Microscopy on EM structural studies.
Selected references:

• Deshaies RJ & Joazeiro CA. 2009. RING domain E3 ubiquitin ligases. 
Annu Rev Biochem. 78:399-434.

• Chu J et al 2009. A mouse forward genetics screen identifies LISTERIN 
as an E3 ubiquitin ligase involved in neurodegeneration. Proc Natl Acad 
Sci USA 106:2097-103.

• Li W et al 2008. Genome-wide and functional annotation of human E3 
ubiquitin ligases identifies MULAN, a mitochondrial E3 that regulates 
the organelle's dynamics and signaling. PLoS One 3(1):e1487.

• Joazeiro CA, Wing SS, Huang H, Leverson JD, Hunter T, Liu YC. 1999. 
The tyrosine kinase negative regulator c-Cbl as a RING-type, 
E2-dependent ubiquitin-protein ligase. Science 286:309-12.

The candidate should have strong conceptual and experimental background 
in biochemistry and molecular biology, as well as on the study of 
molecular mechanisms. Additional experience with ribosomes and protein 
synthesis would be desirable, but is not required. Most importantly, the 
candidate should be independent, hard working, proactive and productive, 
and should enjoy working in a committed team effort to make projects 

Please send CV, a brief statement of research interests, and the names 
and contact information of three references to:

Claudio Joazeiro
c/o Miriam Berba (Email: mirberba at scripps.edu)
The Scripps Research Institute, CB-168
10550 N Torrey Pines Rd
La Jolla, CA 92037

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