[3dem] PhD Oppertunity

Roland Fleck RFleck at nibsc.ac.uk
Mon Oct 20 08:36:51 PDT 2008

Dear Sir/Madam, 


I am not sure if it is possible for you to circulate the following to the 3DEM network, however, if it is possible I would be grateful if you could circulate the details to any suitable candidates and/or colleagues who may have students who may be interested 


The student I had appointed to the position described below has had to withdraw, at short notice, due to changes in their personal circumstances.  As such, I presently have a fully funded PhD studentship available for a suitable candidate.  The position is registered at Imperial College London within the NHLI, Faculty of Medicine. The project will involve both ultra-structural studies (inc. tomography), proteomics and electrophysiological studies.  The laboratories involved are well equipped and resourced with dedicated access to much of the equipment being provided to the student.  


I would ideally like to appoint someone as soon as possible, however, I can be flexible regarding start dates.  If you could ask any suitable candidates to contact me directly (rfleck at nibsc.ac.uk), I would be most grateful.  


Many thanks and best wishes





Division of Cell Biology and Imaging/Proteomics, Hertfordshire, UK


Applications are invited for a 3-year PhD studentship funded by the National

Institute for Biological Standards and Control, in conjunction with Imperial

College, London where the student will be registered and co-supervised.


Project: Differentiation and maturation of hESCM-derived cardiomyocytes.


Differentiation of human embryonic stem cell (hESC) lines can produce

functional cardiomyocytes. However, it remains to be determined why

there are differences between lines in their proclivity for cardiac

differentiation and how to increase the proportion of cardiomyocytes

produced even from permissive lines. This is key to their use as a model

system for cardiac physiology, pathophysiology, drug development

toxicology and regenerative medicine. The project, will adopt a

multi-disciplinary approach for characterization and optimization

of hESC-CM production and maturation. Please see full project

outline at www.nibsc.ac.uk.


Candidates should have, or expect to obtain, a 1 or 2i class degree in

an appropriate life sciences degree, or a 2ii degree plus a post-graduate

degree at MSc level. An interest in cell biology, proteomics and microscopy

are important together with laboratory experience in one or more of the

key interest areas.

Students will be paid a tax-free stipend of £16,000 per annum. Fees are

only available to support EU students.


To express interest or make informal enquiries please e-mail, as soon as possible, Roland Fleck rfleck at nibsc.ac.uk



¦ Dr. Roland A. Fleck

¦ Head of Biological Imaging and Assay Development

¦ hpc Registered Clinical Scientist


¦ rfleck at nibsc.ac.uk <mailto:rfleck at nibsc.ac.uk> 


¦ National Institute of Biological Standards and Control

¦ Cell Biology and Imaging

¦ Blanche Lane

¦ South Mimms

¦ Potters Bar

¦ Herts. EN6 3QG


¦ t + 44 (0) 1707.641000

¦ m + 44 (0) 7779.633158

¦ f + 44 (0) 1707.641050


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