Interpolation of scanned images

[Kasim Sader]

Hi,

I am trying to reduce the resolution of my scanned images while 
retaining the maximum signal possible.  Does anyone have advice on 
which method would be best?  The SPIDER   manual suggests fourier 
filtration (FQ) followed by decimation (DC- is this the same as a 
nearest neighbor reduction?).  However, I have read a paper that used 
2-fold binning of the scanned data- is the decimation with summation of 
neighbouring pixels (DC S) operation the same as binning?  How do the 
two methods of reduction compare?

Thanks,

Kasim Sader