Postdoc position available

[Jenny Hinshaw]

Postdoctoral Position Available
Laboratory of Cell Biochemistry and Biology
National Institute of Health, USA

The focus of the laboratory is to examine the structure/function 
relationship of large macromolecular complexes within the cell.  One 
major focus of the laboratory is to determine if a common mechanism 
of action exists for the diverse dynamin family of proteins. Dynamin 
is crucial for endocytosis, synaptic membrane recycling, membrane 
trafficking within the cell and more recently has been associated 
with filamentous actin.  Other dynamin family members are involved in 
mitochondria division and morphology (Drp1, Mgm1), anti-viral 
activity (Mx, hGBP1), and plant cell wall  formation and thylakoid 
membrane organization (Phragmoplastin, ADLs). To determine if a 
common mechanism exists among this unique set of proteins, we plan to 
calculate and compare the 3D structure of dynamin family members 
using cryo-electron microscopy, helical reconstruction  and single 
particle methods. Another interest of the laboratory is to determine 
the 3-dimensional structure of the nuclear pore complex (NPC) in C. 
Elegans.  This project will entail developing a method of isolating 
NPCs from C. Elegans and comparing various NPC mutants using the C. 
Elegans well-developed genetic system.  The 3D structure of Xenopus 
NPC was previously solved by Drs. Hinshaw, Carragher and Milligan and 
will be used as a model system for developing the C. Elegans system. 

With its diverse laboratories and expertise available on campus, and 
excellent seminars, NIH provides a superb and stimulating scientific 
environment that greatly enhances the postdoctoral training 
experience.  Within our laboratory we have a Philips CM120 electron 
microscope, as well as all the necessary biochemical and molecular 
biology equipment. We also share a state-of-the art FEI/Philips CM30 
Helium-cooled electron microscope.

Contact:  Jenny E. Hinshaw

Laboratory of Cell Biochemistry and Biology
NIDDK, NIH
Building 8, Room 419
8 Center Dr MSC 0851
Bethesda, MD 20892, USA

phone: +1 301 594 0842
fax: +1 301 496 9431
e-mail: jennyh at helix.nih.gov
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